n-Hexane

Overview

EPA's assessment of the noncancer health effects and carcinogenic potential of n-hexane was last prepared and added to the IRIS data base in 1990. The IRIS program is updating the IRIS assessment for n-hexane; this update will incorporate health effects information published since the last assessment was prepared as well as new risk assessment methods. The IRIS assessment for n-hexane will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physicochemical and toxicokinetic properties of the chemical and its toxicity in humans and experimental systems. The assessment will present reference values for noncancer effects of n-hexane (RfD and RfC) and a cancer assessment, where supported by available data. The Toxicological Review and IRIS Summary will be subject to internal peer consultation, Agency review, and external scientific peer review.

History/Chronology

Date	Description
Feb 2005	EPA released the external review draft for public review and comment.
Mar 2005	EPA hosted an independent peer review panel workshop to discuss the draft report.
Dec 2005	EPA released the final Toxicological Review and IRIS Summary for n-Hexane.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• N-Hexane External Peer Review Charge (PDF)  (2  pp, 18.6 KB, about PDF)
• N-Hexane External Peer Review Charge Toxicological Review (PDF)  (162  pp, 4.3 MB, about PDF)
• N-Hexane External Peer Review Charge IRIS Summary (PDF)  (28  pp, 175.8 KB, about PDF)

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Federal Register Notices

• FR NOTICE: FEBRUARY 11, 2005