1,3-Butadiene
CASRN 106-99-0 | DTXSID3020203
- IRIS Summary (PDF) (27 pp, 182.6 KB)
- Supporting Documents for 1,3-Butadiene
Health Assessment Document for 1,3-Butadiene (External Review Draft)
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Overview
The best estimate of human lifetime extra cancer risk from chronic exposure to 1,3-butadiene is 9 X 10-3 per ppm based on a linear extrapolation of the increased leukemia risks observed in occupationally exposed workers. The corresponding estimate of the chronic exposure level of 1,3-butadiene resulting in an extra cancer risk of 10-6 (i.e., one in a million) is 0.1 ppb.
1,3-Butadiene also causes a variety of reproductive and developmental effects in mice and rats; no human data on these effects are available. There are insufficient data from which to draw any conclusions on potentially sensitive subpopulations.
Citation
Additional Information
Comment period has been extended from 4/10/98 to 4/17/98.
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