IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010

IRIS

1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

Toxicological Review (PDF) (419 pp, 3.5 MB)
IRIS Summary (PDF) (32 pp, 284.2 KB)

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Overview
Background
Downloads

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Overview

EPA is releasing the draft report, Toxicological Review for 1,4-Dioxane and IRIS summary, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from DoD from the science discussion are also provided.

Citation

U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010. U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/005D, 2010.

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Background

The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

History/Chronology

Date	Description
01- Aug 1988	EPA released the assessment for 1,4-Dioxane.
02- Oct 2003	The IRIS reassessment of 1,4-dioxane was started.
03- May 2009	EPA released an external review draft for public review and comment.
04- Sep 2009	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.
05- Aug 2010	EPA releases the final assessment and the interagency review draft with comments.

Status

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

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Download(s)

Toxicological Review of 1,4-dioxane (Interagency Science Discussion Draft) (PDF) (298 pp, 2.6 MB, about PDF)
1,4-Dioxane Summary (Interagency Science Discussion Draft) (PDF) (18 pp, 146.5 KB, about PDF)
DoD Comments on 1,4-Dioxane (PDF) (5 pp, 37.1 KB, about PDF)

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