CASRN 123-91-1 | DTXSID4020533

IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010

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EPA is releasing the draft report, Toxicological Review for 1,4-Dioxane and IRIS summary, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from DoD from the science discussion are also provided.


U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010. U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/005D, 2010.

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The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.


Date Description
01- Aug 1988 EPA released the assessment for 1,4-Dioxane.
02- Oct 2003 The IRIS reassessment of 1,4-dioxane was started.
03- May 2009 EPA released an external review draft for public review and comment.
04- Sep 2009 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.
05- Aug 2010 EPA releases the final assessment and the interagency review draft with comments.


Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

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