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1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

  • Toxicological Review (PDF)  (419  pp, 3.5 MB, about PDF)
  • IRIS Summary (PDF)  (32  pp, 284.2 KB, about PDF)
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IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Discussion Draft) 2010

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is releasing the draft report, Toxicological Review for 1,4-Dioxane and IRIS summary, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from DoD from the science discussion are also provided.

Background

The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

History/Chronology
Date Description
Aug 1988 EPA released the assessment for 1,4-Dioxane.
Oct 2003 The IRIS reassessment of 1,4-dioxane was started.
May 2009 EPA released an external review draft for public review and comment.
Sep 2009 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.
Aug 2010 EPA releases the final assessment and the interagency review draft with comments.

Status

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

Download(s)

  • Toxicological Review of 1,4-dioxane (Interagency Science Discussion Draft) (PDF)  (298  pp, 2.6 MB, about PDF)
  • 1,4-Dioxane Summary (Interagency Science Discussion Draft) (PDF)  (18  pp, 146.5 KB, about PDF)
  • DoD Comments on 1,4-Dioxane (PDF)  (5  pp, 37.1 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Related Links

  • EPA Chemicals Dashboard - 1,4-Dioxane
  • eChemPortal - Dioxane

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Chemical Structure for
1,4-Dioxane

1,4-Dioxane

Synonyms

  • diethylene dioxide
  • diethylene ether
  • diethylene oxide
  • dioxane
  • dioxane, 1,4-
  • dioxyethylene ether
  • p-dioxane
  • 1,4-diethylene dioxide
  • 1,4-dioxane
  • 123-91-1
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Last updated on February 27, 2024
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