trans-1,2-Dichloroethylene

Overview

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of cis- and trans-1,2-dichloroethylene that will appear in the Integrated Risk Information System (IRIS) database.

Background

The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

History/Chronology

Date	Description
Sep 1988	EPA posted the trans-1,2-dichloroethylene assessment (RfD only).
Dec 1990	EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009	EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene.
Sep 2009	EPA released an external review draft of the assessment for public review and comment.
Nov 2009	EPA announces the details of an external peer review workshop to be held on December 17, 2009 in a November 10, 2009 Federal Register Notice.
Jan 2010	EPA releases the comments from the public comment period and external review workshop.

Status

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0348 (for the docket ID).

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of Cis-and Trans-1,2-Dichloroethylene (External Review Draft) (PDF)  (150  pp, 908.2 KB, about PDF)
• Charge to External Peer Reviewers (PDF)  (3  pp, 14.6 KB, about PDF)
• Consolidated Comments from the External Peer Review (Final) (PDF)  (48  pp, 205.1 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

• McCauley et al 1990. The effects of subacute and subchronic oral exposure to cis-1,2-dichloroethylene in rats (PDF)  (44  pp, 783.2 KB, about PDF)
• IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Final Report)
• IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)
• IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)

Federal Register Notices

• FR Notice: Nov 10, 2009
• FR Notice: Sep 24, 2009