Comparing Single and Repeated Dosimetry Data for Perfluorooctane Suflonate in Rats
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Overview
Perfluorooctane sulfonate (PFOS) is a member of a class of perfluorinated chemicals used in a variety of consumer and industrial applications because of their oleophobic and hydrophobic properties. It has been shown to cause toxicity in adult and developing laboratory animals. Because PFOS has also been shown to be widely distributed throughout the environment, there have been concerns about its potential health risk to humans. Little is known about the effects of PFOS in humans; however, existing pharmacokinetic and toxicity studies in laboratory animals can be useful in cross-species extrapolations needed to evaluate internal dosimetry in humans.
Citation
HARRIS, L. A. AND H. A. BARTON. Comparing Single and Repeated Dosimetry Data for Perfluorooctane Suflonate in Rats. Taylor & Francis, Inc., Philadelphia, PA, 181(3):148-156, (2008).
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