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1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

  • Toxicological Review (PDF)  (419  pp, 3.5 MB, about PDF)
  • IRIS Summary (PDF)  (32  pp, 284.2 KB, about PDF)
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IRIS Toxicological Review of 1,4-Dioxane (External Review Draft, 2009)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of 1,4-dioxane that when finalized will appear on the Integrated Risk Information System (IRIS) database.

Background

The draft Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

History/Chronology
Date Description
Aug 1988 EPA released the assessment for 1,4-Dioxane.
Oct 2003 The IRIS reassessment of 1,4-dioxane was initiated.
May 2009 EPA released an external review draft for public review and comment.
Jun 2009 EPA announced a public listening session to be held July 6, 2009 and an external peer review workshop to be held on August 17, 2009 for the draft review report. A correction notice was posted on June 17, 2009 to confirm the listening session date as July 6, 2009.
Nov 2009 EPA releases the comments from the public comment period and external review workshop.

Status

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0210 (for the docket ID).

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of 1,4-Dioxane (External Review Draft) (PDF) (PDF)  (276  pp, 2.3 MB, about PDF)
  • Charge to External Peer Reviewers (PDF)  (3  pp, 17.6 KB, about PDF)
  • Consolidated Comments from the External Peer Review (Final) (PDF)  (69  pp, 327.1 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Federal Register Notices

  • FR Notice: Jun 9, 2009
  • FR Notice: May 7, 2009

Related Links

  • EPA Chemicals Dashboard - 1,4-Dioxane
  • eChemPortal - Dioxane

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Chemical Structure for
1,4-Dioxane

1,4-Dioxane

Synonyms

  • diethylene dioxide
  • diethylene ether
  • diethylene oxide
  • dioxane
  • dioxane, 1,4-
  • dioxyethylene ether
  • p-dioxane
  • 1,4-diethylene dioxide
  • 1,4-dioxane
  • 123-91-1
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Last updated on October 19, 2015
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