IRIS Toxicological Review of Ammonia (External Review Draft)

IRIS

Ammonia

CASRN 7664-41-7 | DTXSID0023872

Toxicological Review (PDF) (99 pp, 976.6 KB)
IRIS Executive Summary (PDF) (10 pp, 301.8 KB)
Supplemental Information on the Toxicological Review of Ammonia (Inhalation)
Status: Development of the ammonia (re)assessment has been suspended.

On this page:

Overview
Background
Downloads

Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ammonia that will appear in the Integrated Risk Information System (IRIS) database.

Citation

U.S. EPA. IRIS Toxicological Review of Ammonia (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/013A, 2012.

Top of Page

Background

About 80% of commercially produced ammonia is used in agricultural fertilizers. Ammonia is also used as a corrosion inhibitor, in water purification, as a household cleaner, as an antimicrobial agent in food products, as a refrigerant, as a stabilizer in the rubber industry, as a source of hydrogen in the hydrogenation of fats and oils, and as a chemical intermediate in the production of pharmaceuticals, explosives, and other chemicals. Ammonia is also used to reduce nitrogen oxide emissions from combustion sources such as industrial and municipal boilers, power generators, and diesel engines. Ammonia is a component of the global nitrogen cycle and is essential to many biologic processes.

History/Chronology

Date	Description
01- May 1991	The RfC for ammonia was posted to the IRIS database.
07- Mar 2012	EPA hosted an interagency science consultation meeting on the review of the draft Toxicological Review of Ammonia.
08- Jun 2012	EPA released the external review draft of the ammonia assessment for public review and comment. [Federal Register Notice Jun 8, 2012]

Status

Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Top of Page

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of Ammonia (External Review Draft) (PDF) (83 pp, 1.4 MB, about PDF)
IRIS Toxicological Review of Ammonia, Supplemental Information (External Review Draft) (PDF) (87 pp, 1.3 MB, about PDF)
NCEA Proposed Draft Charge to the External Peer Review (PDF) (3 pp, 115.2 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

IRIS Toxicological Review of Ammonia (Interagency Science Consultation Draft)

Federal Register Notices

Top of Page

US EPA

IRIS

Ammonia

CASRN 7664-41-7 | DTXSID0023872