CASRN 92-52-4 | DTXSID4020161

IRIS Toxicological Review of Biphenyl (External Review Draft) (September 2011)

On this page:

Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.


EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of biphenyl that will appear in the Integrated Risk Information System (IRIS) database.


U.S. EPA. IRIS Toxicological Review of Biphenyl (External Review Draft) (September 2011). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/005A, 2011.

Top of Page


Biphenyl is an organic compound that forms colorless crystals. It occurs naturally in coal tar, crude oil, and natural gas. Biphenyl was once used in the production of polychlorinated biphenyls (PCBs) before they were banned in the late 1970s. It is no longer used as an antimicrobial and a fungicide in the U.S., but it is still used as a fungistat in other countries, most commonly in the packaging of citrus fruits. Today, biphenyl is mainly used in the production of pesticides, as a dye carrier in polyester dyeing, and as a component of heat transfer fluids, which are used for industrial processing applications. Biphenyl is found at multiple Superfund sites and other hazardous waste sites. It is on the list of Hazardous Air Pollutants (HAPs) and is classified as one of the High Production Volume (HPV) chemicals.


Date Description
01- Aug 1989 The RfD for 1,1-biphenyl was posted to the IRIS Database.
02- Mar 1991 The cancer assessment for 1,1-biphenyl was posted to the IRIS database.
03- Jul 2011 EPA hosted an interagency science consultation on the review of the draft Toxicological Review of Biphenyl.
04- Sep 2011 EPA released the external review draft of the biphenyl assessment for public review and comment. [Federal Register Notice Sep 30, 2011]
05- Apr 2012 The external peer review workshop was held.
07- Apr 2013 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Biphenyl.
08- Aug 2013 EPA released the final report in the IRIS Database.


Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2011-0739 (for the docket ID) to comment on this report.

Top of Page


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Top of Page