1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

Toxicological Review (PDF) (419 pp, 3.5 MB, about PDF)
IRIS Summary (PDF) (32 pp, 284.2 KB, about PDF)

IRIS Toxicological Review of 1,4-Dioxane (Final Report, 2010)

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Overview
Background
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Overview

EPA announced the release of the final report, Toxicological Review of 1,4-Dioxane (CAS No. 123-91-1): In Support of Summary Information on the Integrated Risk Information System (IRIS). The final Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.

History/Chronology
Date	Description
Aug 1988	EPA released the assessment for 1,4-Dioxane.
Oct 2003	The IRIS reassessment of 1,4-dioxane was started.
May 2009	EPA released an external review draft for public review and comment.
Sep 2009	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.
Aug 2010	EPA releases the final report and the interagency review draft with comments.

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This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

IRIS Toxicological Review and Summary Documents for 1,4 Dioxane (2010 Final) (PDF) (319 pp, 3.8 MB, about PDF)
IRIS Summary of 1,4 Dioxane

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