Acetone
CASRN 67-64-1 | DTXSID8021482
- Toxicological Review (PDF) (85 pp, 1.1 MB)
- IRIS Summary (PDF) (26 pp, 223.6 KB)
IRIS Toxicological Review of Acetone (External Review Draft)
Notice - This site contains archived material(s)
Archive disclaimer
Archived files are provided for reference purposes only.
The file was current when produced, but is no longer maintained and may now be outdated.
Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance.
Please use the contact us form if you need additional support.
Overview
and adhesives, and is the primary ingredient in most commercial nail polish removers. It is also listed as a contaminant on more than 560 National Priority List Superfund sites.
Acetone's levels of production and variety of uses, coupled with it's volatility and water solubility, result in a high potential for exposure to acetone.
The draft Toxicological Review for Acetone (ToxR) identifies blood and kidney effects as critical effects, with a reference dose (RfD) of 0.3 mg/kg/d. The draft ToxR provides a new RfD based on a drinking water study to replace
a lower RfD derived from a gavage study. The draft ToxR does not propose a reference concentration (RfC) and proposes a cancer weight-of-evidence determination of class D not
classifiable as to human carcinogenicity under the Guidelines for Carcinogen Risk Assessment (1986). Both determinations are consistent with the existing IRIS assessment. The cancer weight of evidence under the Proposed Guidelines for Carcinogen Risk Assessment (1996) is "cannot be determined."
Background
Additional Information
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Acetone (PDF) (51 pp, 185.5 KB, about PDF)
- IRIS Summary - Acetone (PDF) (15 pp, 33.2 KB, about PDF)
If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.