Statistical Inferences from Formaldehyde Dna-Protein Cross-Link Data

IRIS

Formaldehyde

CASRN 50-00-0 | DTXSID7020637

IRIS Summary (PDF) (17 pp, 129.9 KB)
EPA'S Workshop on Formaldehyde (April 2014)
Status: formaldehyde is in step 5 at this time.

On this page:

Overview

Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

Physiologically-based pharmacokinetic (PBPK) modeling has reached considerable sophistication in its application in the pharmacological and environmental health areas. Yet, mature methodologies for making statistical inferences have not been routinely incorporated in these applications except in a few data-rich cases. In this paper, we work with a previously developed PBPK model for the formation and disposition of DNA-protein cross-links formed by inhaled formaldehyde in the nasal lining of rats and rhesus monkeys and provide improved statistical inference on estimated model parameters. We purposefully choose this model because it is based on sparse time course data.

Citation

Klein, M., B. Sinha, AND R. SUBRAMANIAM. Statistical Inferences from Formaldehyde Dna-Protein Cross-Link Data. Taylor & Francis, Inc., Philadelphia, PA, 21(1):42-55, (2010).

Top of Page