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2009 Status Report: Advances In Inhalation Dosimetry of Gases and Vapors With Portal of Entry Effects In the Upper Respiratory Tract

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice

The U.S. EPA has released the final status report entitled Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract.

Overview

This status report provides a review of the advances in the state of the science for interspecies inhalation gas dosimetry related to the upper respiratory tract (URT) or nasal tract region.

Background

This report reviews advances in the state of the science for inhalation gas dosimetry related to the URT or nasal tract region that have occurred since the publication of the Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry; EPA/600/8-90/066F, October 1994 (RfC Methods). The RfC Methods document provides the basis for EPA extrapolation of data from animal toxicology studies to estimate delivered dose in humans as part of the development of inhalation reference values (i.e., RfC values).The primary results from this review include empirical information related to the assumptions underlying the current methodology used by EPA, as well as how the state of the science and advanced dosimetry modeling techniques inform these assumptions. The intent of this report is to serve as a source document for revisions to the Agency’s RfC Methods. The report makes clear that it is intended neither to displace the current procedures for gas dosimetry in RfC Methods nor to reflect on use of these procedures in assessments currently in IRIS.

History/Chronology
Date Description
Jun 2009 Internal EPA workgroup review and management review.
Jul 2009 Revised report submitted to independent, external peer review.
Aug 2009 Revised final report based on peer review comments.
Sep 2009 EPA released the final report.

Status

This is the final report.

Download(s)

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

  • Status Report: Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract (PDF)  (100  pp, 876.0 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Database
  • Methods For Derivation Of Inhalation Reference Concentrations (RfCs) And Application Of Inhalation Dosimetry
  • 2011 Status Report: Advances In Inhalation Dosimetry For Gases With Lower Respiratory Tract and Systemic Effects
  • Advances In Inhalation Gas Dosimetry For Derivation of A Reference Concentration (RfC) and Use In Risk Assessment
  • IRIS Home
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Last updated on September 19, 2012
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