IRIS Toxicological Review of Chloroprene (Interagency Science Discussion Draft)

IRIS

Chloroprene

CASRN 126-99-8 | DTXSID5020316

Toxicological Review (PDF) (303 pp, 4.4 MB)
IRIS Summary (PDF) (30 pp, 299.8 KB)
Systematic Review of Chloroprene (Jan 2018)

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Overview
Background
Downloads

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Overview

EPA is releasing the draft report, Toxicological Review of Chloroprene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Citation

U.S. EPA. IRIS Toxicological Review of Chloroprene (Interagency Science Discussion Draft) . U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/010D, 2010.

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Background

The draft Toxicological Review of chloroprene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to chloroprene. Chloroprene (C4H5Cl) is a volatile, flammable liquid used primarily in the manufacture of polychloroprene or neoprene rubber. The latter is used to make diverse products, such as tires, wire coatings, and tubing. Human health risk concerns for chloroprene are primarily related to exposures via effluent and emissions from facilities that use chloroprene to produce polychloroprene elastomers or transport the product, although these exposure concerns have not been well characterized.

This assessment contains the derivation of a chronic inhalation reference concentration (RfC) and chronic cancer inhalation unit risk.

History/Chronology

Date	Description
01- 1999	The IRIS reassessment of chloroprene was initiated in 1999. Currently there is no entry in the IRIS database for chloroprene.
02- Sep 2009	EPA released the external review draft for public review and comment.
03- Nov 2009	EPA announced the public listening session to be held on November 23, 2009 in a November 5, 2009 Federal Register Notice.
04- Dec 2009	EPA announced an external peer review workshop to be held on January 6, 2010 in a December 1, 2009 Federal Register Notice.
05- Feb 2010	EPA released the comments from the public comment period and external review workshop.
06- Jul 2010	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Chloroprene.
07- Sep 2010	EPA released the final toxicological report and IRIS Summary for Chloroprene and the interagency science discussion draft with comments.

Status

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Toxicological Review of Chloroprene (Interagency Science Discussion Draft) (PDF) (315 pp, 2.8 MB, about PDF)
Chloroprene Summary (Interagency Science Discussion Draft) (PDF) (24 pp, 199.2 KB, about PDF)
Chloroprene CEQ IASD Comments (PDF) (2 pp, 44.9 KB, about PDF)
Chloroprene NIEHS IASD Comments (PDF) (1 pp, 26.4 KB, about PDF)
Chloroprene OMB IASD Comments (PDF) (2 pp, 21.5 KB, about PDF)

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