trans-1,2-Dichloroethylene

Overview

On September 24, 2009, the Toxicological Review of cis- and trans-1,2-dichloroethylene and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation drafts of the cis- and trans-1,2-dichloroethylene IRIS Toxicological Review and charge to external peer reviewers are posted on this site.

Background

The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

History/Chronology

Date	Description
Sep 1988	EPA posted the trans-1,2-dichloroethylene assessment (RfD only).
Dec 1990	EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009	EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene . These comments are provided on this web site.
Sep 2009	EPA released an External Review Draft of the assessment for public review and comment.

Status

Following external peer review of the Toxicological Review of 1,2-dichloroethylene, the assessment will be revised, to respond to external peer review and public comments, will undergo a final EPA internal review and a review by and science discussion with other federal agencies and White House offices, and will be posted to the IRIS database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Toxicological Review of cis- and trans-1,2-dichloroethylene (Interagency Science Consultation Draft) (PDF)  (152  pp, 802.7 KB, about PDF)
• Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF)  (3  pp, 15.6 KB, about PDF)
• 1. Department of Defense Comments on the Toxicological Review of cis- and trans-1,2-dichloroethylene (Interagency Science Consultation Draft) (PDF)  (3  pp, 28.3 KB, about PDF)
• 2. Department of Defense Comments on the draft Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF)  (1  pp, 18.6 KB, about PDF)

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Document Related Link(s)

• IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Final Report)
• IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)
• IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)