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1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

  • Toxicological Review (PDF)  (419  pp, 3.5 MB, about PDF)
  • IRIS Summary (PDF)  (32  pp, 284.2 KB, about PDF)
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IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of 1,4-Dioxane (with inhalation update) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

Background

1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. Additional information regarding 1,4-dioxane toxicity resulting from exposure via inhalation has now been incorporated into the 2010 assessment without changing the oral toxicity conclusions of the previous assessment.

History/Chronology
Date Description
Aug 1988 EPA released the assessment for 1,4-Dioxane.
Oct 2003 The IRIS reassessment of 1,4-dioxane was initiated.
May 2009 EPA released an external review draft for public review and comment.
Sep 2009 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of 1,4-dioxane.
Aug 2010 EPA released the final assessment of 1,4-dioxane on the IRIS Web site.
May 2011 EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.
Sep 2011 EPA released the external review draft (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.
Sep 2011 EPA extended the close of the public comment period to November 15, 2011. [Federal Register Notice Sep16, 2011]
Feb 2012 EPA announced that an independent panel of experts will meet in Morrisville, NC on March 19, 2012 to discuss the draft report. [Federal Register Notice Feb 13, 2012]
May 2012 EPA released the comments from the public comment period and external review workshop.

Status

Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2011-0390" (for the docket ID) to comment on this report.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of 1,4-Dioxane (Inhalation) (External Review Draft) (PDF)  (374  pp, 3.7 MB, about PDF)
  • Charge to External Peer Reviewers (PDF)  (4  pp, 48.8 KB, about PDF)
  • Consolidated Comments from the External Peer Review (Final) (PDF)  (58  pp, 2.1 MB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)

Federal Register Notices

  • FR Notice: Feb 13, 2012
  • FR Notice: Sep 16, 2011
  • FR Notice: Aug 31, 2011

Related Links

  • EPA Chemicals Dashboard - 1,4-Dioxane
  • eChemPortal - Dioxane

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Chemical Structure for
1,4-Dioxane

1,4-Dioxane

Synonyms

  • diethylene dioxide
  • diethylene ether
  • diethylene oxide
  • dioxane
  • dioxane, 1,4-
  • dioxyethylene ether
  • p-dioxane
  • 1,4-diethylene dioxide
  • 1,4-dioxane
  • 123-91-1
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Last updated on March 19, 2019
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