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1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

  • Toxicological Review (PDF)  (419  pp, 3.5 MB, about PDF)
  • IRIS Summary (PDF)  (32  pp, 284.2 KB, about PDF)
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IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

On September 9, 2011, the Toxicological Review of 1,4-Dioxane (with inhalation update) (External Review Draft) was posted for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science consultation draft of the IRIS Toxicological Review of 1,4-dioxane and the charge to external peer reviewers are posted on this site.

Background

1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. Additional information regarding 1,4-dioxane toxicity resulting from exposure via inhalation has now been incorporated into the 2010 assessment without changing the oral toxicity conclusions of the previous assessment.

History/Chronology
Date Description
Aug 2010 EPA released the final assessment of 1,4-dioxane on the IRIS Web site.
May 2011 EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane.
Sep 2011 EPA released the external review draft of the 1,4-dioxane assessment (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.

Status

Following external peer review the assessment will be revised taking into consideration external peer review and public comments. The revised assessment will undergo a final EPA internal review and review by other federal agencies and White House offices, then the final assessment will be posted to the IRIS database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft) (PDF)  (401  pp, 4.6 MB, about PDF)
  • draft Charge to External Peer Reviewers (Interagency Science Consultation draft) (PDF)  (3  pp, 55.7 KB, about PDF)
  • EPA's Response and Comments from the Interagency Science Consultation (PDF)  (31  pp, 168.9 KB, about PDF)
  • 1. CDC ATSDR 1,4-dioxane IASC Comments (PDF)  (2  pp, 52.7 KB, about PDF)
  • 2. DoD 1,4-dioxane IASC Comments (PDF)  (16  pp, 208.0 KB, about PDF)
  • 3. NASA 1,4-dioxane IASC Comments (PDF)  (2  pp, 28.3 KB, about PDF)
  • 4. NIEHS NTP 1,4-dioxane IASC Comments (PDF)  (1  pp, 12.7 KB, about PDF)
  • 5. OMB 1,4-dioxane IASC Comments (PDF)  (3  pp, 26.4 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)

Related Links

  • EPA Chemicals Dashboard - 1,4-Dioxane
  • eChemPortal - Dioxane

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Chemical Structure for
1,4-Dioxane

1,4-Dioxane

Synonyms

  • diethylene dioxide
  • diethylene ether
  • diethylene oxide
  • dioxane
  • dioxane, 1,4-
  • dioxyethylene ether
  • p-dioxane
  • 1,4-diethylene dioxide
  • 1,4-dioxane
  • 123-91-1
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Last updated on March 19, 2019
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