IRIS Toxicological Review of 1,4-Dioxane (With Inhalation Update) (Final Report)

IRIS

1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

Toxicological Review (PDF) (419 pp, 3.5 MB)
IRIS Summary (PDF) (32 pp, 284.2 KB)

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Overview
Background
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Overview

The final IRIS Toxicological Review of 1,4-dioxane (with inhalation update) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.

Citation

U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (With Inhalation Update) (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/003F, 2013.

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History/Chronology

Date	Description
07- Aug 2010	EPA released the final assessment of 1,4-dioxane on the IRIS Web site.
08- May 2011	EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane (Inhalation).
10- Aug 2011	EPA released the external review draft for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.
11- Sep 2011	EPA extended the close of the public comment period to November 15, 2011. [Federal Register Notice Sep16, 2011]
12- Feb 2012	EPA announced that an independent panel of experts will meet in Morrisville, NC on March 19, 2012 to discuss the draft report. [Federal Register Notice Feb 13, 2012]
13- May 2012	EPA released the comments from the public comment period and external review workshop.
14- Sep 2013	EPA posted the final Toxicological Review of 1,4-Dioxane (inhalation) to the IRIS database.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (EPA/635/R-11/003F) (PDF) (419 pp, 3.7 MB, about PDF)

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