CASRN 123-91-1 | DTXSID4020533

IRIS Toxicological Review of 1,4-Dioxane (With Inhalation Update) (Final Report)

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The final IRIS Toxicological Review of 1,4-dioxane (with inhalation update) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.


U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (With Inhalation Update) (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/003F, 2013.

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Date Description
07- Aug 2010 EPA released the final assessment of 1,4-dioxane on the IRIS Web site.
08- May 2011 EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane (Inhalation).
10- Aug 2011 EPA released the external review draft for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.
11- Sep 2011 EPA extended the close of the public comment period to November 15, 2011. [Federal Register Notice Sep16, 2011]
12- Feb 2012 EPA announced that an independent panel of experts will meet in Morrisville, NC on March 19, 2012 to discuss the draft report. [Federal Register Notice Feb 13, 2012]
13- May 2012 EPA released the comments from the public comment period and external review workshop.
14- Sep 2013 EPA posted the final Toxicological Review of 1,4-Dioxane (inhalation) to the IRIS database.

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