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1,4-Dioxane

CASRN 123-91-1 | DTXSID4020533

  • Toxicological Review (PDF)  (419  pp, 3.5 MB, about PDF)
  • IRIS Summary (PDF)  (32  pp, 284.2 KB, about PDF)
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IRIS Toxicological Review of 1,4-Dioxane (With Inhalation Update) (Final Report)

On this page:

  • Overview
  • Background
  • Downloads

Overview

The final IRIS Toxicological Review of 1,4-dioxane (with inhalation update) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane. Human health risk concerns for 1,4-dioxane are primarily related to exposure from drinking, ground, and surface waters, although these exposure concerns have not been well characterized. 1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coatings, adhesive agent, and an ingredient in chemical manufacture.


History/Chronology
Date Description
Aug 2010 EPA released the final assessment of 1,4-dioxane on the IRIS Web site.
May 2011 EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane (Inhalation).
Aug 2011 EPA released the external review draft for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response.
Sep 2011 EPA extended the close of the public comment period to November 15, 2011. [Federal Register Notice Sep16, 2011]
Feb 2012 EPA announced that an independent panel of experts will meet in Morrisville, NC on March 19, 2012 to discuss the draft report. [Federal Register Notice Feb 13, 2012]
May 2012 EPA released the comments from the public comment period and external review workshop.
Sep 2013 EPA posted the final Toxicological Review of 1,4-Dioxane (inhalation) to the IRIS database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (EPA/635/R-11/003F) (PDF)  (419  pp, 3.7 MB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)
  • IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)

Related Links

  • EPA Chemicals Dashboard - 1,4-Dioxane
  • eChemPortal - Dioxane

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Chemical Structure for
1,4-Dioxane

1,4-Dioxane

Synonyms

  • diethylene dioxide
  • diethylene ether
  • diethylene oxide
  • dioxane
  • dioxane, 1,4-
  • dioxyethylene ether
  • p-dioxane
  • 1,4-diethylene dioxide
  • 1,4-dioxane
  • 123-91-1
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Last updated on February 01, 2017
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