IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials, 2014)

IRIS

Chromium(VI)

CASRN 18540-29-9 | DTXSID7023982

Toxicological Review (PDF) (538 pp, 9.6 MB)
IRIS Summary (PDF) (14 pp, 461.9 KB)

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Overview
Background
Downloads

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Overview

In August 2014, EPA released the second part of draft literature searches and associated search strategies, evidence tables, and exposure response arrays for Cr(VI) to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

Draft literature search strategies

The approach for identifying studies
The screening process for selecting pertinent studies
The resulting list of pertinent studies

Preliminary evidence tables
- The process for selecting studies to include in evidence tables
- The quality of the studies in the evidence tables

The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

Citation

U.S. EPA. IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials, 2014). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/218, 2014.

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History/Chronology

Date	Description
01- April 2014	EPA released preliminary meeting materials for chromium (VI) in preparation for the June 2014 Bimonthly Public Science Meeting.
02- Jun 2014	EPA hosted a public science meeting to discuss preliminary literature materials.
03- Aug 2014	EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting.
04- Oct 2014	EPA hosted a public science meeting to discuss preliminary literature materials (part 2).

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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