Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
CASRN 121-82-4 | DTXSID9024142
IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (External Review Draft)
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Overview
Citation
Background
An oral reference dose (RfD) and an oral cancer slope factor are currently available on IRIS. A reassessment of the human health effects of RDX, including both cancer effects and effects other than cancer, is being undertaken.
History/Chronology
| Date | Description |
|---|---|
| Aug 2013 | EPA released preliminary draft materials for discussion at the December IRIS Bimonthly Public Meeting. |
| Dec 2013 | EPA discussed preliminary draft materials at the December 12-13, 2013 IRIS Bimonthly Public Meeting. Presentations are also available on the meeting web site. |
| Mar 2016 | EPA released the public comment draft for a 60-day review period and announced it will be discussed at the May 10, 2016 IRIS Public Science Meeting. EPA also released the interagency science consultation documents, comments from reviewers, and EPA's response to major comments. [Federal Register Notice: Mar 10, 2016] |
| Mar 2016 | EPA announced a request for nominations of experts to augment the SAB CAAC for the review of the draft RDX assessment. Any related questions should be directed to the SAB. [SAB Federal Register Notice Mar 18, 2016] |
| May 2016 | EPA discussed the draft RDX Toxicological Review at the May IRIS Public Science Meeting. |
| Sep 2016 | EPA released the external review draft for peer review by EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC). Any related questions should be directed to the SAB. [SAB Federal Register Notice Sep 29, 2016] |
| Dec 2016 | EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) convened a 3-day meeting to conduct a peer review of the draft Toxicological Review. |
| Apr 2017 | EPA's Science Advisory Board (SAB) held a 2-day public external peer review teleconference to discuss the draft Toxicological Review. [Federal Register Notice Mar 22, 2017] |
Status
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (External Review Draft) (PDF) (163 pp, 2.2 MB, about PDF)
- IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) -- Supplemental Information (External Review Draft) (PDF) (161 pp, 2.2 MB, about PDF)
- Draft Charge to External Peer Reviewers (External Review Draft) (PDF) (6 pp, 140.6 KB, about PDF)
- Review of EPA’S Draft Assessment Entitled Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)
- Agency Response to Peer Review Report for RDX
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Document Related Link(s)
- SAB: IRIS Assessment for Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) Activity Information
- IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials)
- IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Public Comment Draft)
- IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft)
Federal Register Notices
Docket
Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2013-0430Critical Effect Systems
Tumor Sites
Chemical Structure for
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
