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Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

CASRN 121-82-4 | DTXSID9024142

  • Toxicological Review (PDF)  (187  pp, 2.5 MB, about PDF)
  • IRIS Executive Summary (PDF)  (7  pp, 875.0 KB, about PDF)
  • Supplemental Information on the IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)
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IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (External Review Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis supporting the RDX assessment and release a final report of their review. Information regarding the peer review can be found on the SAB website.

Background

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX, or Royal Demolition eXplosive) is a military explosive with limited civilian uses. In the United States, RDX is produced at Army ammunition plants; it is not produced commercially.

An oral reference dose (RfD) and an oral cancer slope factor are currently available on IRIS. A reassessment of the human health effects of RDX, including both cancer effects and effects other than cancer, is being undertaken.

History/Chronology
Date Description
Aug 2013 EPA released preliminary draft materials for discussion at the December IRIS Bimonthly Public Meeting.
Dec 2013 EPA discussed preliminary draft materials at the December 12-13, 2013 IRIS Bimonthly Public Meeting. Presentations are also available on the meeting web site.
Mar 2016 EPA released the public comment draft for a 60-day review period and announced it will be discussed at the May 10, 2016 IRIS Public Science Meeting. EPA also released the interagency science consultation documents, comments from reviewers, and EPA's response to major comments. [Federal Register Notice: Mar 10, 2016]
Mar 2016 EPA announced a request for nominations of experts to augment the SAB CAAC for the review of the draft RDX assessment. Any related questions should be directed to the SAB. [SAB Federal Register Notice Mar 18, 2016]
May 2016 EPA discussed the draft RDX Toxicological Review at the May IRIS Public Science Meeting.
Sep 2016 EPA released the external review draft for peer review by EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC). Any related questions should be directed to the SAB. [SAB Federal Register Notice Sep 29, 2016]
Dec 2016 EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) convened a 3-day meeting to conduct a peer review of the draft Toxicological Review.
Apr 2017 EPA's Science Advisory Board (SAB) held a 2-day public external peer review teleconference to discuss the draft Toxicological Review. [Federal Register Notice Mar 22, 2017]

Status

Following external peer review, the assessment will be revised taking into consideration peer review comments. The assessment will then undergo a final EPA internal review and a review by other federal agencies and the Executive Office of the President. Once final, the assessment will be posted to the IRIS database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (External Review Draft) (PDF)  (163  pp, 2.2 MB, about PDF)
  • IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) -- Supplemental Information (External Review Draft) (PDF)  (161  pp, 2.2 MB, about PDF)
  • Draft Charge to External Peer Reviewers (External Review Draft) (PDF)  (6  pp, 140.6 KB, about PDF)
  • Review of EPA’S Draft Assessment Entitled Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)
  • Agency Response to Peer Review Report for RDX

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • SAB: IRIS Assessment for Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) Activity Information
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Public Comment Draft)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft)

HERO Project

  • Primary Literature Search References Sorted By Author (RDX)

Federal Register Notices

  • SAB FR Notice: Mar 22, 2017
  • SAB FR Notice: Sep 29, 2016

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2013-0430

Related Links

  • EPA Chemicals Dashboard - Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
  • eChemPortal - Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Critical Effect Systems

Nervous
Nervous

Reproductive
Reproductive

Urinary
Urinary

Tumor Sites

Hepatic
Hepatic

Respiratory
Respiratory

Chemical Structure for
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Synonyms

  • Cyclonite
  • Cyclotrimethylenenitramine
  • Cyclotrimethylenetrinitramine
  • Cyklonit
  • Esaidro-1,3,5-trinitro-1,3,5-triazina
  • Giekfol
  • Heksoflen
  • Heksogen
  • Hexahydro-1,3,5-trinitro-1,3,5-triazin
  • Hexahydro-1,3,5-trinitro-1,3,5-triazine
  • Hexahydro-1,3,5-trinitro-s-triazine
  • Hexogeen
  • Hexogen
  • Hexogen 5w
  • Hexolite
  • NSC 312447
  • PBX(AF) 108
  • PBX-MVF
  • PBXN(AF) 108
  • PBXW 108(e)
  • RDX
  • Research Development Explosive
  • Royal Demolition eXplosive
  • T4
  • Trimethyleentrinitramine
  • Trimethylenetrinitramine
  • Trinitrocyclotrimethylene triamine
  • UN 0072
  • UN 0483
  • perhydro-1,3,5-trinitro-1,3,5-triazine; RDX
  • s-Triazine, hexahydro-1,3,5-trinitro-
  • sym-Trimethylenetrinitramine
  • trinitrotrimethylenetriamine
  • 1,3,5-Triazine, hexahydro-1,3,5-trinitro-
  • 1,3,5-Trinitro-1,3,5-triazacyclohexane
  • 1,3,5-Trinitrohexahydro-s-triazine
  • 1,3,5-triaza-1,3,5-trinitrocyclohexane
  • 1,3,5-trinitro-1,3,5-triazinane
  • 1,3,5-trinitrohexahydro-1,3,5-triazine
  • 1,3,5-trinitroperhydro-1,3,5-triazine
  • 121-82-4
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Last updated on March 07, 2018
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