CASRN 67-66-3 | DTXSID1020306

Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials)

On this page:


EPA announced the availability of the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) for a 30-day public comment period. Information regarding the implementation of systematic review in the IRIS Program is described in a January 2018 Memo.


In January 2018, EPA released the Systematic Review Protocol for the Chloroform IRIS Assessment (Inhalation). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.


U.S. EPA. Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-17/486, 2018.

Top of Page


Chloroform (trichloromethane) is a colorless, volatile liquid with a distinct odor. Chloroform is nonflammable. It is slightly soluble in water and is readily miscible with most organic solvents. Because chloroform is relatively volatile, it tends to escape from contaminated environmental media (e.g., water or soil) into air, and may also be released in vapor form from some types of industrial or chemical operations.

Therefore, humans may be exposed to chloroform not only by ingestion of chloroform in drinking water, food, or soil, but also by dermal contact with contaminated media (especially water) and by inhalation of vapor (especially in indoor air).


Date Description
01- Sep 1984 EPA released the Health Effects Assessment for Chloroform.
02- Apr 1988 EPA released the Updated Health Effects Assessment for Chloroform.
03- Oct 2001 EPA released the final toxicological report and summary document and posted these to the IRIS database.
04- Sep 2017 EPA released the IRIS Assessment Plan (IAP) for Chloroform for public comment and review. [Federal Register Notice Sep 18, 2017]
05- Sep 2017 EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) discussed the draft document at a public meeting on September 27-28, 2017.
06- Jan 2018 EPA released the Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials). [Federal Register Notice Jan 31, 2018]


The IRIS Program will use the systematic review protocol to develop the draft assessment.

Top of Page


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Federal Register Notices


Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2017-0497

Top of Page

Quick Check

Quick check is a visual indication of the current step that this IRIS assessment has started or is in.