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Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

CASRN 121-82-4 | DTXSID9024142

  • Toxicological Review (PDF)  (187  pp, 2.5 MB, about PDF)
  • IRIS Executive Summary (PDF)  (7  pp, 875.0 KB, about PDF)
  • Supplemental Information on the IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)
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IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Discussion Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

In August 2018, EPA finalized the IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX). The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices in May 2018. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science discussion materials provided to other agencies, including the interagency review draft are posted on this site.

Background

Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX, or Royal Demolition eXplosive) is a military explosive with limited civilian uses. In the United States, RDX is produced at Army munitions plants; it is not produced commercially.

History/Chronology
Date Description
Dec 2013 EPA discussed preliminary draft materials at the December 12-13, 2013 IRIS Bimonthly Public Meeting. Presentations are also available on the meeting web site.
Mar 2016 EPA released the public comment draft for a 60-day review period and announced it will be discussed at the May 10, 2016 IRIS Public Science Meeting. EPA also released the interagency science consultation documents, comments from reviewers, and EPA's response to major comments. [Federal Register Notice: Mar 10, 2016]
Mar 2016 EPA announced a request for nominations of experts to augment the SAB CAAC for the review of the draft RDX assessment. Any related questions should be directed to the SAB. [SAB Federal Register Notice Mar 18, 2016]
May 2016 EPA discussed the draft RDX Toxicological Review at the May IRIS Public Science Meeting.
Sep 2016 EPA released the external review draft for peer review by EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC). Any related questions should be directed to the SAB. [SAB Federal Register Notice Sep 29, 2016]
Dec 2016 EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) convened a 3-day meeting to conduct a peer review of the draft Toxicological Review.
Apr 2017 EPA's Science Advisory Board (SAB) held a 2-day public external peer review teleconference to discuss the draft Toxicological Review. [Federal Register Notice Mar 22, 2017]
May 2018 EPA submitted a revised draft for final Agency Review and Interagency Science Discussion.
Aug 2018 EPA posted the final IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) and summary to the IRIS database.

Status

The RDX assessment has been loaded into the IRIS website and database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Discussion Draft) (PDF)  (179  pp, 2.9 MB, about PDF)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Discussion Draft) - Supplemental Information (PDF)  (208  pp, 2.6 MB, about PDF)
  • 1. DoD Comments on Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (PDF)  (3  pp, 32.2 KB, about PDF)
  • EPA’s Response to Interagency Comments (PDF)  (2  pp, 144.5 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Public Comment Draft)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Consultation Draft)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (External Review Draft)
  • IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Final Report)

Related Links

  • EPA Chemicals Dashboard - Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
  • eChemPortal - Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Critical Effect Systems

Nervous
Nervous

Reproductive
Reproductive

Urinary
Urinary

Tumor Sites

Hepatic
Hepatic

Respiratory
Respiratory

Chemical Structure for
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

Synonyms

  • Cyclonite
  • Cyclotrimethylenenitramine
  • Cyclotrimethylenetrinitramine
  • Cyklonit
  • Esaidro-1,3,5-trinitro-1,3,5-triazina
  • Giekfol
  • Heksoflen
  • Heksogen
  • Hexahydro-1,3,5-trinitro-1,3,5-triazin
  • Hexahydro-1,3,5-trinitro-1,3,5-triazine
  • Hexahydro-1,3,5-trinitro-s-triazine
  • Hexogeen
  • Hexogen
  • Hexogen 5w
  • Hexolite
  • NSC 312447
  • PBX(AF) 108
  • PBX-MVF
  • PBXN(AF) 108
  • PBXW 108(e)
  • RDX
  • Research Development Explosive
  • Royal Demolition eXplosive
  • T4
  • Trimethyleentrinitramine
  • Trimethylenetrinitramine
  • Trinitrocyclotrimethylene triamine
  • UN 0072
  • UN 0483
  • perhydro-1,3,5-trinitro-1,3,5-triazine; RDX
  • s-Triazine, hexahydro-1,3,5-trinitro-
  • sym-Trimethylenetrinitramine
  • trinitrotrimethylenetriamine
  • 1,3,5-Triazine, hexahydro-1,3,5-trinitro-
  • 1,3,5-Trinitro-1,3,5-triazacyclohexane
  • 1,3,5-Trinitrohexahydro-s-triazine
  • 1,3,5-triaza-1,3,5-trinitrocyclohexane
  • 1,3,5-trinitro-1,3,5-triazinane
  • 1,3,5-trinitrohexahydro-1,3,5-triazine
  • 1,3,5-trinitroperhydro-1,3,5-triazine
  • 121-82-4
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Last updated on August 30, 2018
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