IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Final Report)

IRIS

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)

CASRN 121-82-4 | DTXSID9024142

Toxicological Review (PDF) (187 pp, 2.5 MB)
IRIS Executive Summary (PDF) (7 pp, 875.0 KB)
Supplemental Information on the IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX)

On this page:

Overview
Background
Downloads

Overview

EPA has finalized the Integrated Risk Information System (IRIS) assessment of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX). This assessment addresses the potential cancer and noncancer human health effects from exposure to RDX. Now final, this assessment updates the toxicological information on RDX posted to the IRIS database in 1988 and 1990. EPA’s program and regional offices may use this assessment to inform decisions to protect human health.

Citation

U.S. EPA. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/211F, 2018.

Top of Page

Background

Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX, or Royal Demolition eXplosive) is a military explosive with limited civilian uses. In the United States, RDX is produced at Army munitions plants; it is not produced commercially.

History/Chronology

Date	Description
02- Dec 2013	EPA discussed preliminary draft materials at the December 12-13, 2013 IRIS Bimonthly Public Meeting. Presentations are also available on the meeting web site.
03- Mar 2016	EPA released the public comment draft for a 60-day review period and announced it will be discussed at the May 10, 2016 IRIS Public Science Meeting. EPA also released the interagency science consultation documents, comments from reviewers, and EPA's response to major comments. [Federal Register Notice: Mar 10, 2016]
04- Mar 2016	EPA announced a request for nominations of experts to augment the SAB CAAC for the review of the draft RDX assessment. Any related questions should be directed to the SAB. [SAB Federal Register Notice Mar 18, 2016]
05- May 2016	EPA discussed the draft RDX Toxicological Review at the May IRIS Public Science Meeting.
06- Sep 2016	EPA released the external review draft for peer review by EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC). Any related questions should be directed to the SAB. [SAB Federal Register Notice Sep 29, 2016]
07- Dec 2016	EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) convened a 3-day meeting to conduct a peer review of the draft Toxicological Review.
08- Apr 2017	EPA's Science Advisory Board (SAB) held a 2-day public external peer review teleconference to discuss the draft Toxicological Review. [Federal Register Notice Mar 22, 2017]
09- May 2018	EPA submitted a revised draft for final Agency Review and Interagency Science Discussion.
10- Aug 2018	EPA posted the final IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) and summary to the IRIS database.

Top of Page

Download(s)

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.