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Chromium(VI)

CASRN 18540-29-9 | DTXSID7023982

  • Toxicological Review (PDF)  (538  pp, 9.6 MB, about PDF)
  • IRIS Summary (PDF)  (14  pp, 461.9 KB, about PDF)
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Updated Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials, 2019)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

In March 2019, EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

Background

This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

The IRIS Program posts assessment protocols and protocol updates publicly on a chemical’s HERO project page, the IRIS website, and in systematic review repositories such as Zenodo (https://zenodo.org/record/2654896#.XMsScOhKjcs).

History/Chronology
Date Description
Apr 2014 EPA released preliminary meeting materials for chromium (VI), part 1, in preparation for the June 2014 Bimonthly Public Science Meeting.
Jun 2014 EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 1.
Aug 2014 EPA released preliminary meeting materials for chromium (VI), part 2, in preparation for the October 2014 Bimonthly Public Science Meeting.
Oct 2014 EPA hosted a public science meeting to discuss preliminary meeting materials for chromium (VI), part 2.
Mar 2019 EPA released the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Mar 15, 2019]
Apr 2019 EPA announced that they will host a public science meeting on April 24, 2019 (by webinar) to discuss the draft document.
Oct 2022 EPA released an update to the IRIS hexavlent chromium protocol.
Aug 2024 EPA released the final IRIS hexavalent chromium protocol.

Status

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Preliminary Assessment Materials) (PDF)  (41  pp, 1.8 MB, about PDF)
  • An Update to the Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (Oct 2022)
  • Final Systematic Review Protocol for the Hexavalent Chromium IRIS Assessment (August 2024) (PDF)  (159  pp, 2.0 MB, about PDF)
  • IRIS Public Science Meeting (April 2019) -- Hexavalent Chromium

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • EPA-HQ-ORD-2014-0313
  • IRIS Toxicological Review of Hexavalent Chromium Part 1: Experimental Animal Studies (Preliminary Assessment Materials, 2014)
  • IRIS Toxicological Review of Hexavalent Chromium Part 2: Human, Toxicokinetic, and Mechanistic Studies (Preliminary Assessment Materials, 2014)

HERO Project

  • Primary Literature Search References Sorted by Author (Chromium VI)

Federal Register Notices

  • FR Notice: Mar 15, 2019

Related Links

  • EPA Chemicals Dashboard - Chromium(VI)
  • eChemPortal - Chromium(VI)

Critical Effect Systems

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Tumor Sites

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Chemical Structure for
Chromium(VI)

Chromium(VI)

Synonyms

  • Chromic ion
  • Chromium
  • Chromium (VI)
  • Chromium (VI) ion
  • Chromium, ion
  • 18540-29-9
  • 7440-47-3
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Last updated on December 26, 2023
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