Perfluorononanoic Acid (PFNA)

CASRN 375-95-1 | DTXSID8031863

Status: perfluorononanoic acid (pfna) is in step 6 at this time.

Systematic Review Protocol for the Perfluorononanoic Acid (PFNA) IRIS Assessment (Preliminary Assessment Materials)

On this page:

Overview
Background
Downloads

Overview

In November 2019, EPA released the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments for a 45-day public comment period. As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a chemical-specific systematic review of the available scientific literature. Protocols include strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

Background

This protocol includes strategies for literature searches, criteria for study inclusion or exclusion, considerations for evaluating study methods, information management for extracting data, approaches for synthesis within and across lines of evidence, and methods for derivation of toxicity values.

The IRIS Program posts assessment protocols and protocol updates publicly on a chemical’s HERO project page, the IRIS website, and in systematic review repositories such as Zenodo (https://zenodo.org/record/2654896#.XMsScOhKjcs).

History/Chronology
Date	Description
Nov 2019	EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]

Status

The IRIS Program will use the methods for conducting the systematic review as described in the protocol to develop the draft assessment.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

An Update to the Systematic Review Protocol for the PFBA, Pfhxa, Pfhxs, PFNA, and PFDA IRIS Assessments (Jan 2021) (PDF) (208 pp, 3.3 MB, about PDF)

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