IRIS

tert-Butyl Alcohol (tBA)

CASRN 75-65-0 | DTXSID8020204

IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Interagency Science Discussion Draft, 2020)

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Overview

In August 2021, EPA finalized the IRIS assessment of tert-butyl alcohol (TBA). The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices after public release in June 2017. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science discussion materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) are posted on this site.

Citation

U.S. EPA. IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Interagency Science Discussion Draft, 2020). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-20/105, 2020.

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Background

tert-Butyl Alcohol (tBA) is used as a solvent; as a denaturant for ethanol and several other alcohols; in the manufacture of flotation agents, fruit essences, and perfumes; as an octane booster in gasoline; as a dehydrating agent; and as a chemical intermediate in the manufacture of methyl methacrylate. tBA's production for industrial uses may result in its direct release to the environment through various waste streams. tBA is also a likely degradation product of methyl tert-butyl ether (MTBE). Probable routes of human exposure to tBA include inhalation, ingestion, and skin or eye contact.

History/Chronology

Date Description
01- Aug 2013 EPA released preliminary assessment materials (draft literature searches and associated search strategies, evidence tables and exposure response arrays) for discussion at an IRIS Public Science Meeting.
02- Dec 2013 EPA discussed tert-butanol at the December 2013 IRIS public science meeting.
03- Sep 2014 EPA sent an interagency science consultation draft for review and comment.
04- May 2016 EPA released the public comment draft for public review and comment.
05- Jun 2016 EPA convened a public science meeting June 29-30, 2016 to discuss the public comment draft.
06- Jun 2017 EPA released the external review draft and charge to reviewers prior to the public peer review meeting.[SAB FR Notice Jun 16, 2017]
07- Jul 2017 EPA's Science Advisory Board (SAB) hosted a public teleconference to discuss the draft assessment.
08- Aug 2017 EPA's SAB hosted a 2-day public meeting on August 15-17, 2017, to discuss the draft assessment.
09- Feb 2019 EPA's SAB released a final report of their review of the draft IRIS assessment.
10- Jul 2020 EPA submitted the revised interagency science discussion draft for final Agency and Interagency review.
11- Aug 2021 EPA posts the final report IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) and released the interagency science discussion draft and comments to the IRIS database.

Status

Now that the interagency review draft has been completed and finalized, the TBA assessment has been loaded into the IRIS Web site and Database.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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