Perfluorobutanoic Acid (PFBA)
CASRN 375-22-4 | DTXSID4059916
IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Public Comment and External Review Draft, 2021)
Notice
Overview
Citation
Background
PFBA is a breakdown product of other PFAS that are used in stain-resistant fabrics, paper food packaging, and carpets; it is also used for manufacturing photographic film, and it is used as a substitute for longer chain perfluoroalkyl carboxylic acids (PFCAs) in consumer products. PFBA has been found to accumulate in agricultural crops and has been detected in household dust, soils, food products, and surface, ground, and drinking water.
As such, exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFBA-containing products.
History/Chronology
Date | Description |
---|---|
Nov 2019 | EPA released the Systematic Review Protocol for the PFAS IRIS Assessments (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019] |
Jul 2020 | EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. |
Aug 2020 | EPA sent an interagency science consultation PFBA draft for review and comment. |
Aug 2021 | EPA released the draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid for a 60-day public comment period and external peer review. Additionally, EPA announced the solicitation for the nominations of members to a PFAS IRIS Review Panel that will review all five assessments. [Federal Register Notice Aug 23, 2021] |
Oct 2021 | EPA extended the public comment period until November 8, 2021. EPA additionally updated the draft and supplemental information documents and included an erratum to clarify that the assessment addresses the PFBA free acid as well as simple salts of PFBA. [Federal Register Notice Oct 20, 2021] |
Feb 2022 | ERG, a contractor to EPA, hosted an independent public peer review meeting from February 22-23, 2022, to discuss the review of the IRIS assessment of PFBA and related salts. |
Jun 2022 | ERG, a contractor to EPA, submitted their final peer review report to EPA on the review of the IRIS assessment of PFBA and related salts (see downloads). |
Status
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Public Comment and External Review Draft, Oct 2021) (PDF) (129 pp, 2.8 MB, about PDF)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts - Supplemental Information (Public Comment and External Review Draft, Oct 2021) (PDF) (90 pp, 1.5 MB, about PDF)
- PFBA Errata Sheet (PDF) (1 pp, 117.2 KB, about PDF)
- PFBA Draft Charge to External Peer Reviewers (Public Comment and External Review Draft) (PDF) (6 pp, 202.1 KB, about PDF)
- External Panel Peer Review of EPA's Draft "IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts" Final Peer Review Report (PDF) (107 pp, 1.0 MB, about PDF)
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Document Related Link(s)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid (Public Comment and External Review Draft, Aug 2021) (PDF) (130 pp, 2.9 MB, about PDF)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid - Supplemental Information (Public Comment and External Review Draft, Aug 2021) (PDF) (91 pp, 1.5 MB, about PDF)
- Systematic Review Protocol for the PFAS IRIS Assessments (2021)
- Toxicological Review of Perfluorobutanoic Acid and Related Compound Ammonium Perfluorobutanoic Acid (PFBA) (Interagency Science Consultation Draft, 2020)
- External Peer Review Activities for PFBA Integrated Risk Information System (IRIS) Assessment (Nov 2021)