Perfluorononanoic Acid (PFNA)
CASRN 375-95-1 | DTXSID8031863
IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft)
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Overview
In March 2024, the IRIS Program released the draft IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts for public comment and external peer review. The IRIS assessment of PFNA will undergo an independent external scientific peer review managed by ERG, a contractor to EPA. Additional information about the peer review meeting is listed with the downloads below and located on the external peer review meeting site.
Citation
U.S. EPA. IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-24/031, 2024.
Background
Perfluorononanoic Acid (PFNA) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water. Concerns about PFNA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment.
PFNA has been used to make fluoropolymers, a coating that can resist heat, water, and chemicals; thus, PFNA can be present in products including carpets, food-contact papers, and cleaning and polishing products. Low levels of PFNA are detected in aqueous film-forming foam (AFFF) for fire suppression. PFNA is also a breakdown product of other PFAS (e.g. 8:2 fluorotelomer alcohol).
PFNA has been used to make fluoropolymers, a coating that can resist heat, water, and chemicals; thus, PFNA can be present in products including carpets, food-contact papers, and cleaning and polishing products. Low levels of PFNA are detected in aqueous film-forming foam (AFFF) for fire suppression. PFNA is also a breakdown product of other PFAS (e.g. 8:2 fluorotelomer alcohol).
History/Chronology
| Date | Description |
|---|---|
| Nov 2019 | EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019] |
| Jul 2020 | EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. |
| Jul 2023 | EPA sent an interagency science consultation PFNA draft for review and comment. |
| Mar 2024 | EPA released the draft IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts for a 60-day public comment period and external peer review. The comments on the Interagency Science Consultation Draft were also released. [Federal Register Notice: March 7, 2024 ] |
Status
The toxicological review of Perfluorononanoic Acid (PFNA) and related salts was released for a 60-day public comment period and external peer review. Following the external peer review meeting, the assessment will be revised, taking into consideration all public and external peer review comments received.
Additional Information
If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please contact Dahnish Shams (shams.dahnish@epa.gov) AND hotline.iris@epa.gov. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft, Mar 2024) (PDF) (575 pp, 16.6 MB, about PDF)
- Draft External Peer Review Charge Questions for the IRIS Toxicological Review of Perfluorononanoic Acid and Related Salts (PDF) (10 pp, 341.8 KB, about PDF)
- IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft, Mar 2024) Supplemental Information (PDF) (270 pp, 4.8 MB, about PDF)
If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.
Document Related Link(s)
- External Peer Review Activities for PFNA Integrated Risk Information System (IRIS) Assessment
- IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Interagency Science Consultation Draft, 2023)
- Systematic Review Protocol for the Perfluorononanoic Acid (PFNA) IRIS Assessment (Preliminary Assessment Materials)
- Systematic Review Protocol for the PFAS Iris Assessments (2021)
Federal Register Notices
Docket
Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2021-0560Quick Check
Chemical Structure for
Perfluorononanoic Acid (PFNA)
