Perfluorohexanesulfonic Acid (PFHxS)
CASRN 355-46-4 | DTXSID7040150
IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts (Interagency Science Consultation Draft, 2023)
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Overview
Citation
Background
PFHxS is used in water- and stain-protective coatings for consumer products such as carpets, textiles, paper (including food-contact), packaging (including food-contact), textiles, and electronics. It has been used industrially as a surfactant to make fluoropolymers, as a surfactant or surface protection agent for cleaning and polishing products, and in other industrial fluids or water-proofing agents. It may also be present unintentionally as an impurity from industrial production processes. PFHxS has also been used in aqueous film-forming foam (AFFF) for fire suppression.
History/Chronology
| Date | Description |
|---|---|
| Nov 2019 | EPA released the Systematic Review Protocol for the PFHxS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019] |
| Jul 2020 | EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. |
| Jan 2023 | EPA sent an interagency science consultation PFHxS draft for review and comment. |
| Jul 2023 | EPA released the draft IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts for a 60-day public comment period and external peer review. EPA also released the interagency science consultation comments from reviewers. [Federal Register Notice Jul 11, 2023] |
Status
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- 1. ATSDR PFHxS IASC Comments Jan 2023 (PDF) (7 pp, 181.6 KB, about PDF)
- 2. DoD PFHxS IASC Comments Jan 2023 (PDF) (30 pp, 453.1 KB, about PDF)
- 3. EOP PFHxS IASC Comments Jan 2023 (PDF) (4 pp, 203.1 KB, about PDF)
- 4. NIEHS PFHxS IASC Comments Jan 2023 (PDF) (9 pp, 262.7 KB, about PDF)
- 5. NIOSH PFHxS IASC Comments Jan 2023 (PDF) (3 pp, 192.4 KB, about PDF)
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Chemical Structure for
Perfluorohexanesulfonic Acid (PFHxS)
