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Cobalt and Cobalt Compounds

CASRN 1307-96-6 | DTXSID6051649

  • IRIS Public Science Meeting on Cobalt and Cobalt Compounds (Jan 2023)
  • Status: cobalt and cobalt compounds is in step 3 at this time.
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IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice

EPA announced the availability of the IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials) for a 30-day public comment period as announced in the Federal Register. The deadline for comments is Dec 14, 2022. [FR Notice: Nov 14, 2022]

Overview

In November 2022, EPA released the Draft IRIS Assessment Plan (IAP) and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure and outcome measures. EPA also released the IRIS assessment protocol for cobalt, which describes the methodology for how the assessment will be conducted, including dose-response methods.

Background

Cobalt is a metallic element that is naturally occurring as several different substances and oxidation states, often in association with nickel, silver, lead, copper, and iron ores. Cobalt compounds represent a large group of substances and are used in a variety of industrial applications including as a colorant for glass, ceramics, and paint; as driers for inks and paints; as catalysts; and in feed supplements and batteries. Cobalt is also used in alloys or composites. The cancer assessment of water-soluble and water-insoluble cobalt compounds is focused on inhalation exposure from emissions to air during industrial processes and those cobalt forms most pertinent to implementing the Clean Air Act (CAA).

History/Chronology
Date Description
Nov 2022 EPA released the draft IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds for a 30-day public comment and review period. [Federal Register Notice Nov 14, 2022]

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (PDF)  (88  pp, 2.2 MB, about PDF)
  • IRIS Public Science Meeting on Cobalt and Cobalt Compounds (Jan 2023)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Federal Register Notices

  • FR Notice: Dec 2, 2022
  • FR Notice: Nov 14, 2022

Docket

Comments on the assessment may be submitted and reviewed using the Docket ID EPA-HQ-ORD-2022-0833

Quick Check

Image text: 1. Draft Development, 2. Agency Review, 3. (highlighted) Interagency Science Consultation, 4. Public Comment and External Peer Review, 5. Revise Assessment, 6. Final Agency Review/Interagency Science Discussion, 7. Final Assessment

Related Links

  • EPA Chemicals Dashboard - Cobalt Oxide
  • eChemPortal - Cobalt Oxide

Synonyms

  • Cobalt
  • Cobalt Compounds
  • FCO 178
  • cobalt black
  • cobalt monoxide
  • cobalt(II) oxide
  • cobaltous oxide
  • cobaltoxid
  • (oxido)cobalt
  • 1307-96-6
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Last updated on November 14, 2022
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