Perfluorobutanoic Acid (PFBA)
CASRN 375-22-4 | DTXSID4059916
IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Final Report, 2022)
Notice
Overview
Citation
Background
PFBA is a breakdown product of other PFAS that are used in stain-resistant fabrics, paper food packaging, and carpets; it is also used for manufacturing photographic film, and it is used as a substitute for longer chain perfluoroalkyl carboxylic acids (PFCAs) in consumer products. PFBA has been found to accumulate in agricultural crops and has been detected in household dust, soils, food products, and surface, ground, and drinking water.
As such, exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFBA-containing products.
History/Chronology
Date | Description |
---|---|
Nov 2019 | EPA released the Systematic Review Protocol for the PFAS IRIS Assessments (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019] |
Jul 2020 | EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments. |
Aug 2020 | EPA sent an interagency science consultation PFBA draft for review and comment. |
Aug 2021 | EPA released the draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Compound Ammonium Perfluorobutanoic Acid for a 60-day public comment period and external peer review. Additionally, EPA announced the solicitation for the nominations of members to a PFAS IRIS Review Panel that will review all five assessments. [Federal Register Notice Aug 23, 2021] |
Oct 2021 | EPA extended the public comment period until November 8, 2021. EPA additionally updated the draft and supplemental information documents and included an erratum to clarify that the assessment addresses the PFBA free acid as well as simple salts of PFBA. [Federal Register Notice Oct 20, 2021] |
Feb 2022 | ERG, a contractor to EPA, hosted an independent public peer review meeting from February 22-23, 2022, to discuss the review of the IRIS assessment of PFBA and related salts. |
Jun 2022 | ERG, a contractor to EPA, submitted their final peer review report to EPA on the review of the IRIS assessment of PFBA and related salts (see downloads). |
Nov 2022 | EPA submitted the revised interagency science discussion draft for final Agency and Interagency review. |
Dec 2022 | EPA posted the final report IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (final Report) and released the interagency science discussion draft comments to the IRIS database. |
Status
Download(s)
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (PDF) (145 pp, 3.0 MB, about PDF)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts -- Supplemental Materials (PDF) (138 pp, 1.6 MB, about PDF)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts -- Executive Summary (PDF) (6 pp, 363.3 KB, about PDF)
- Errata Sheet (May 2023) (PDF) (1 pp, 70.3 KB, about PDF)
If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.
Document Related Link(s)
- Systematic Review Protocol for the PFAS IRIS Assessments (2021)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Public Comment and External Review Draft, 2021)
- External Peer Review Activities for PFBA Integrated Risk Information System (IRIS) Assessment (Nov 2021)
- IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and Related Salts (Interagency Science Discussion Draft Comments, 2022)