Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
IRIS
Contact Us

Formaldehyde

CASRN 50-00-0 | DTXSID7020637

  • Toxicological Review (PDF)  (927  pp, 16.3 MB, about PDF)
  • IRIS Executive Summary (PDF)  (10  pp, 450.2 KB, about PDF)
  • Key IRIS
    Values
  • Chemical
    Documents
  • Report
    Details
  • Other EPA
    Information

IRIS Toxicological Review of Formaldehyde (Interagency Science Discussion Draft, 2024)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

In August 2024, EPA finalized the IRIS Toxicological Review of Formaldehyde (Inhalation). The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available on this site.

Background

Formaldehyde is present in a variety of products including plywood adhesives, abrasive materials, insulation, pesticides, and embalming fluids. Major sources of anthropogenic emissions include household furnishings and building materials, motor vehicle exhaust, manufacturing plants that produce or use formaldehyde or substances that contain it (e.g., glues), and tobacco smoke.

History/Chronology
Date Description
May 2011 NAS's Board on Environmental Studies and Toxicology (BEST) releases the NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report).
Apr 2014 EPA convened a state-of-the-science workshop on formaldehyde on April 30 and May 1, 2014 in Arlington, VA. This workshop focused on 3 themes, see the web site for specific details.
Jun 2018 The IRIS Assessment of Formaldehyde-Inhalation Agency Review draft (completed in 2017) is formally suspended.
Mar 2021 EPA updates the list of priority assessments developed by IRIS. EPA unsuspends the IRIS Toxicological Review of Formaldehyde-Inhalation.
Dec 2021 EPA initiated an interagency science consultation on the draft Toxicological Review of Formaldehyde-Inhalation.
Apr 2022 EPA released the draft Toxicological Review of Formaldehyde-Inhalation for public comment and subsequent external peer review by the National Academies of Sciences, Engineering, and Medicine.
Aug 2023 The National Academies of Sciences, Engineering, and Medicine (NASEM) released their consensus study report, Review of EPA's 2022 Draft Formaldehyde Assessment, which provides recommendations to the U.S. EPA.
Jun 2024 EPA submitted the revised interagency science discussion draft for final Agency and Interagency review.

Status

Now that the interagency review draft has been completed and finalized, the final formaldehyde assessment has been published on the IRIS Web site and the toxicity values added to the IRIS Database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • ATSDR Comments on the IASD Draft of Formaldehyde-Inhalation (PDF)  (7  pp, 304.7 KB, about PDF)
  • NIOSH Comments on the IASD Draft of Formaldehyde-Inhalation (PDF)  (2  pp, 163.1 KB, about PDF)
  • USDA Comments on the IASD Draft of Formaldehyde-Inhalation (PDF)  (2  pp, 150.4 KB, about PDF)
  • EPA Presentation - Interagency Step 6 Meeting on the IRIS Formaldehyde Assessment (PDF)  (23  pp, 581.1 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Program Outlook April 2019-Suspended/Discontinued Assessment
  • IRIS Program Outlook Jun 2021-Unsuspended Assessment
  • IRIS Toxicological Review of Formaldehyde-Inhalation (Interagency Science Consultation Draft, 2021)

Related Links

  • EPA Chemicals Dashboard - Formaldehyde
  • EPA Workshop on Formaldehyde (April 2014)
  • IRIS Summary of Formaldehyde (Cancer, 1989)
  • IRIS Summary of Formaldehyde (Noncancer, 1990)
  • Supporting Documents for Formaldehyde
  • eChemPortal - Formaldehyde

Critical Effect Systems

Gastrointestinal
Gastrointestinal

Respiratory
Respiratory

Urinary
Urinary

Tumor Sites

Hematologic
Hematologic

Respiratory
Respiratory

Chemical Structure for
Formaldehyde

Formaldehyde

Synonyms

  • Aldehyd mravenci (Czech)
  • Aldehyde formique (French)
  • Aldeide formica (Italian)
  • BFV
  • FA
  • Formaldehyd (Czech, Polish)
  • Formaldehyde
  • Formaldehyde solution (DOT)
  • Formalin
  • Formalith
  • Formic aldehyde
  • Formol
  • Fyde
  • Hoch
  • Ivalon
  • Karsan
  • Lysoform
  • Methanal
  • Methyl aldehyde
  • Methylene glycol
  • Methylene oxide
  • Morbicid
  • NCI-C02799
  • Oplossingen (Dutch)
  • Oxomethane
  • Oxymethylene
  • Paraform
  • Polyoxymethylene glycols
  • RCRA Waste Number U122
  • Superlysoform
  • UN 1198 (DOT)
  • UN 2209 (DOT)
  • 50-00-0
  • IRIS Home
  • About IRIS
  • IRIS Recent Additions
  • IRIS Calendar
  • IRIS Assessments
  • Advanced Search
  • IRIS Program Materials
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on August 20, 2024
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data.gov
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.