Polychlorinated Biphenyls (PCBs)
CASRN 1336-36-3 | DTXSID5024267
- IRIS Summary (PDF) (22 pp, 146.5 KB)
- Status: polychlorinated biphenyls (pcbs) is in step 1 at this time.
A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures
A protocol was developed that describes the literature search strategy and Populations, Exposures, Comparators, and Outcomes (PECO) criteria used to facilitate subsequent screening and categorization of literature into a systematic evidence map of PCB noncancer health effects across 15 health systems. A comprehensive literature search yielded 62,599 records. After a prioritization step that included machine learning and natural language processing, 17,037 studies were manually screened at the title and abstract level. An additional 900 studies identified by experts or supplemental searches were also included, for a total of 17,937 studies reviewed. After full-text screening of 3,888 references, 1,611 studies met the PECO criteria.
Relevant study details such as the PCB congeners measured or administered, health systems and endpoints assessed, exposure duration, and species were extracted into literature summary tables and used to identify database strengths and gaps that would benefit from further research. Sufficient evidence is available to support PCB assessments for most health systems, but the amount of data to inform associations with specific outcomes differs. Furthermore, despite many years of research, sparse data exist for inhalation and dermal exposures, which are highly relevant human exposure routes. This evidence map provides a foundation for future noncancer hazard assessments of PCB mixtures and for strategic planning of research to fill remaining data gaps.
This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
- A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures (Final Report) (PDF) (192 pp, 7.9 MB, about PDF)
- Supporting Data
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