IRIS

Perfluorodecanoic Acid (PFDA)

CASRN 335-76-2 | DTXSID3031860

Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Interagency Science Discussion Draft, 2024)

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Overview

In July 2024, EPA finalized the IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts. The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices after public release in April 2023. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available on this site.

Citation

U.S. EPA. Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts (Interagency Science Discussion Draft, 2024). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-24/172Fb, 2024.

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Background

Perfluorodecanoic Acid (PFDA) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). PFAS are not naturally occurring in the environment; they are man-made compounds that have been used widely over the past several decades in consumer products and industrial applications because of their resistance to heat, oil, stains, grease, and water. Concerns about PFDA and other PFAS stem from the resistance of these compounds to hydrolysis, photolysis, and biodegradation, which leads to their persistence in the environment. PFDA has been used in stain and grease-proof coatings on food packaging, furniture, upholstery, and carpet. PFDA has also been detected in nano- and impregnation-sprays, outdoor textiles, carpet, gloves, paper-based food contact materials, ski wax, and leather. Exposure is possible via inhalation of indoor or outdoor air, ingestion of drinking water and food, and dermal contact with PFDA-containing products.

History/Chronology

Date Description
01- Nov 2019 EPA released the Systematic Review Protocol for the PFAS IRIS Assessment (Preliminary Assessment Materials). [Federal Register Notice Nov 8, 2019]
02- Jul 2020 EPA released an update to the Systematic Review Protocol for the PFBA, PFHxA, PFHxS, PFNA, and PFDA IRIS Assessments in response to public comments.
03- Mar 2022 EPA sent an interagency science consultation PFDA draft for review and comment.
04- Apr 2023 EPA released the draft IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts for a 60-day public comment period and external peer review. EPA also released the interagency science consultation comments from reviewers. [Federal Register Notice: April 10, 2023 ]
05- Oct 2023 EPA posted the final peer review report from the contractor on the EPA website.
06- Apr 2024 EPA submitted the revised interagency science discussion draft for final Agency and Interagency review.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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Chemical Structure for
Perfluorodecanoic Acid (PFDA)

Perfluorodecanoic Acid (PFDA)