2,3,7,8-Tetrachlorodibenzo-p-dioxin

Overview

The health assessment document on polychlorinated dibenzo-p-dioxins discusses multimedia environmental issues pertaining to the most toxic chlorinated dioxins, namely, 2,3,7,8-tetrachloro-; 1,2,3,7,8-pentachloro-; 1,2,3,6,7,8-hexachloro-; and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxins. Scientifically valid data essential for human health risk assessment purposes from an extensive literature search have been compiled and discussed critically. Discussions are based on physiochemical properties and analytical methodologies; stability and degradation; production, use, synthesis; environmental resources and environmental levels; environmental ffate and transport; degradation; bioaccumulation and bioconcentration factors; ecological effects; various aspects of toxic effects from acute, subchronic and chronic exposures in experimental animals and humans; pharmacokinetics and mechanism of toxic effects; teratogenicity and reproductive effects; mutagenicity and carcinogenecity. Based on this review, critical studies have been identified and utilized for estimating the unit risk.

• HEALTH ASSESSMENT DOCUMENT FOR POLYCHLORINATED DIBENZO-P-DIOXINS (1985). U.S. ENVIRONMENTAL PROTECTION AGENCY, WASHINGTON, D.C., EPA/600/8-84/014F, 1985.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.