Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
IRIS
Contact Us

Toluene

CASRN 108-88-3 | DTXSID7021360

  • Toxicological Review (PDF)  (179  pp, 1.7 MB, about PDF)
  • IRIS Summary (PDF)  (35  pp, 224.6 KB, about PDF)
  • Key IRIS
    Values
  • Chemical
    Documents
  • Report
    Details
  • Other EPA
    Information

IRIS Toxicological Review and Summary Documents For Toluene (Second External Review Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

The U.S. EPA has conducted a second external peer review of the scientific basis supporting the health hazard and dose-response assessment for toluene that will appear on the Agency's online data base, the Integrated Risk Information System (IRIS). The draft Toxicological Review for Toluene and the draft IRIS Summary have undergone internal Agency review and previous external peer review (August 2002). As a result of the peer review, significant changes were made to the documents warranting further peer review. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.


History/Chronology
Date Description
Aug 2002 EPA released the first external review draft.
Jan 2004 EPA released the second external review draft.
Sep 2005 EPA released the final IRIS Toxicological Review and Summary Documents for Toluene.

Additional Information

EPA provided for public information a draft Toxicological Review, draft IRIS Summary, and the charge to external peer reviewers for EPA's health assessment of toluene. These documents are provided for public viewing prior to an external scientific peer review. While EPA is no longer soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to February 19, 2004 were considered in subsequent drafts.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • IRIS Summary for Toluene (PDF)  (26  pp, 133.8 KB, about PDF)
  • Charge to Reviewers for Toxicological Review of Toluene and IRIS Summary (PDF)  (2  pp, 101.6 KB, about PDF)
  • Toxicological Review of Toluene (PDF)  (121  pp, 916.0 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review and Summary Documents For Toluene (External Review Draft)

Federal Register Notices

  • FR NOTICE: JANUARY 15, 2004

Related Links

  • EPA Chemicals Dashboard - Toluene
  • eChemPortal - Toluene

Critical Effect Systems

Nervous
Nervous

Urinary
Urinary

Chemical Structure for
Toluene

Toluene

Synonyms

  • Antisal 1a
  • Benzene, methyl
  • Methacide
  • Methylbenzene
  • Methylbenzol
  • Monomethylbenzene
  • NCI-C07272
  • Phenylmethane
  • RCRA Waste Number U220
  • Tolu-sol
  • Tolueen
  • Toluen
  • Toluene
  • Toluol
  • Toluolo
  • UN 1294
  • 108-88-3
  • IRIS Home
  • About IRIS
  • IRIS Recent Additions
  • IRIS Calendar
  • IRIS Assessments
  • Advanced Search
  • IRIS Program Materials
Contact Us to ask a question, provide feedback, or report a problem.
Last updated on June 24, 2009
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data.gov
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.