IRIS Critical Effect Search Results

Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Cardiovascular"
Number of records: 9

Chemical Name	CASRN	Exposure Route	Critical Effect	RfD/RfC	RfD/RfC Value
Arsenic, Inorganic	7440-38-2	Oral	Ischemic heart disease and type 2 diabetes (see Note)	RFD	6 x 10 ^-5 mg/kg-day
Chlorine dioxide	10049-04-4	Inhalation	Vascular congestion and peribronchial edema	RFC	2 x 10 ^-4 mg/m³
2,3-Dichloropropanol	616-23-9	Oral	Myocardial degeneration, hepatotoxicity and nephrotoxicity	RFD	3 x 10 ^-3 mg/kg-day
3,4-Dimethylphenol	95-65-8	Oral	Changes in blood pressure and body weight histopathological changes in liver, kidney and spleen	RFD	1 x 10 ^-3 mg/kg-day
Endosulfan	115-29-7	Oral	Reduced body weight gain in males and females increased incidence of marked progressive glomerulonephrosis and blood vessel aneurysms in males	RFD	6 x 10 ^-3 mg/kg-day
S-Ethyl dipropylthiocarbamate (EPTC)	759-94-4	Oral	Degenerative cardiomyopathy	RFD	2.5 x 10 ^-2 mg/kg-day
Isoxaben	82558-50-7	Oral	Increased BUN; decreased serum AP and AST; decreased food consumption efficiency; increased heart/body weight	RFD	5 x 10 ^-2 mg/kg-day
Sodium fluoroacetate	62-74-8	Oral	Increased heart weight in females and males; decreased testis weight and altered spermatogenesis in males.	RFD	2 x 10 ^-5 mg/kg-day
Trichlorofluoromethane	75-69-4	Oral	Survival and histopathology (pleuritis and pericarditis)	RFD	3 x 10 ^-1 mg/kg-day