IRIS Critical Effect Search Results

Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Ocular"
Number of records: 9

Chemical Name	CASRN	Exposure Route	Critical Effect	RfD/RfC	RfD/RfC Value
Aroclor 1254	11097-69-1	Oral	Ocular exudate, inflamed and prominent Meibomian glands, distorted growth of finger and toe nails; decreased antibody (IgG and IgM) response to sheep erythrocytes	RFD	2 x 10 ^-5 mg/kg-day
Dacthal	1861-32-1	Oral	Effects on the lungs, liver, kidney, thyroid and thyroid hormones in males and females and eyes of females	RFD	1 x 10 ^-2 mg/kg-day
4,6-Dinitro-o-cyclohexyl phenol	131-89-5	Oral	Cataract formation	RFD	2 x 10 ^-3 mg/kg-day
2,4-Dinitrophenol	51-28-5	Oral	Cataract formation	RFD	2 x 10 ^-3 mg/kg-day
Diquat	2764-72-9	Oral	Minimal lens opacity and cataracts	RFD	2.2 x 10 ^-3 mg/kg-day
Fluridone	59756-60-4	Oral	Glomerulonephritis, atrophic testes, eye keratitis decreased body weight and organ weights	RFD	8 x 10 ^-2 mg/kg-day
Methyl tert-butyl ether (MTBE)	1634-04-4	Inhalation	Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females)	RFC	3 mg/m³
Tetrachloroethylene (Perchloroethylene)	127-18-4	Oral	(See Note)	RFD	6 x 10 ^-3 mg/kg-day
Tetrachloroethylene (Perchloroethylene)	127-18-4	Inhalation	(See Note)	RFC	4 x 10 ^-2 mg/m³