IRIS Home | Critical Effect Search Results

Searches using filters for organ/system affected are limited to effects (or tumor sites) used to derive the RfD, RfC, oral slope factor, or inhalation unit risk. Other effects associated with chemicals in the IRIS database that were not used as the basis for a toxicity value are not searchable with organ/system filters. IRIS Advanced Search searches only final IRIS assessments; to look for information on draft assessments, see Quick Check: Assessments in Development.

Search Filtered by: Critical Effect = "Cardiovascular"
Number of records: 9
Chemical Name CASRN Exposure Route Critical Effect RfD/RfC RfD/RfC Value
Arsenic, Inorganic 7440-38-2 Oral Hyperpigmentation, keratosis and possible vascular complications RFD 3 x 10 -4 mg/kg-day
Chlorine dioxide 10049-04-4 Inhalation Vascular congestion and peribronchial edema RFC 2 x 10 -4 mg/m3
2,3-Dichloropropanol 616-23-9 Oral Myocardial degeneration, hepatotoxicity and nephrotoxicity RFD 3 x 10 -3 mg/kg-day
3,4-Dimethylphenol 95-65-8 Oral Changes in blood pressure and body weight histopathological changes in liver, kidney and spleen RFD 1 x 10 -3 mg/kg-day
Endosulfan 115-29-7 Oral Reduced body weight gain in males and females increased incidence of marked progressive glomerulonephrosis and blood vessel aneurysms in males RFD 6 x 10 -3 mg/kg-day
S-Ethyl dipropylthiocarbamate (EPTC) 759-94-4 Oral Degenerative cardiomyopathy RFD 2.5 x 10 -2 mg/kg-day
Isoxaben 82558-50-7 Oral Increased BUN; decreased serum AP and AST; decreased food consumption efficiency; increased heart/body weight RFD 5 x 10 -2 mg/kg-day
Sodium fluoroacetate 62-74-8 Oral Increased heart weight in females and males; decreased testis weight and altered spermatogenesis in males. RFD 2 x 10 -5 mg/kg-day
Trichlorofluoromethane 75-69-4 Oral Survival and histopathology (pleuritis and pericarditis) RFD 3 x 10 -1 mg/kg-day