IRIS

Cyanide, free

CASRN 57-12-5 | DTXSID6023991

The assessment summary for cyanide, free is based on the Toxicological Review for Hydrogen Cyanide and Cyanide Salts (see related topics). The RfD value for cyanide, free is presented in Section I.A.3 of the IRIS Summary as well as Section 5.1.3 of the toxicological review.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 243 K) Last Updated: 09/28/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Reproductive 6.3 x 10 -4 Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanide, free is presented in section 1.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. 3000 Low/Medium


Note: The RfD for cyanide, free was calculated using toxicological data for CN-. See ("related topics") for additional details.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 243 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (27 pp, 243 K) Last Updated: 03/01/1991

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Pertinent data regarding carcinogenicity have not been located in the available literature.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

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