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Hydrogen Cyanide and Cyanide Salts

CASRN Various | DTXSID1051438

  • Toxicological Review (PDF) (153 pp, 905 K)
  • IRIS Summary (PDF) (27 pp, 243 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 243 K) Last Updated: 09/28/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Reproductive 6 x 10 -4 Decreased cauda epididymis weight in male F344/N rats BMDL (1SD): 1.9
mg/kg-day
3000 Low/Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 243 K) Last Updated: 09/28/2010

System RfC (mg/m3) Basis PoD Composite UF Confidence
Endocrine 8 x 10 -4 Thyroid enlargement and altered iodide uptake LOAEL (ADJ): 2.5
mg/m3
3000 Low/Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (27 pp, 243 K) Last Updated: 09/28/2010

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the U.S. EPA (2005a) Guidelines for Carcinogen Risk Assessment, there is "inadequate information to assess the carcinogenic potential" of cyanide.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 243 K)

Not assessed under the IRIS Program.

Chemical Documents

Sep 2010: IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Final Report) (Report)

Sep 2009: IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft) (Report)

Sep 2008: IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (Interagency Science Discussion Draft) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • Calcium Cyanide
  • Cyanide, Free
  • EPA Chemicals Dashboard - Hydrogen Cyanide and Cyanide Salts
  • Potassium Cyanide
  • Potassium Silver Cyanide
  • Sodium Cyanide
  • eChemPortal - Hydrogen Cyanide and Cyanide Salts

Critical Effects

Endocrine
Endocrine

Reproductive
Reproductive

Synonyms

  • Calcyan, cyanogas
  • Cyanobrik
  • Cyclone B
  • Potassium dicyanoargentate
  • Prussic acid
  • black cyanide
  • hydrocyanic acid
  • white cyanide
  • 143-33-9
  • 151-50-8
  • 460-19-5
  • 506-61-6
  • 74-90-8
  • IRIS Home
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  • IRIS Calendar
  • IRIS Assessments
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