IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)

IRIS

Dichloromethane

CASRN 75-09-2 | DTXSID0020868

Toxicological Review (PDF) (567 pp, 4.9 MB)
IRIS Summary (PDF) (44 pp, 329.1 KB)

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Overview
Background
Downloads

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Overview

On March 31, 2010, the draft IRIS Toxicological Review of Dichloromethane (Methylene Chloride) external review draft document and the charge to external peer reviewers were released for public review and comment. The draft document and the charge to external peer reviewers were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency science consultation draft of the Toxicological Review of Dichloromethane (Methylene Chloride) and the charge to external peer reviewers are posted on this site.

Citation

U.S. EPA. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/003C, 2010.

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Background

The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane. Dichloromethane, also known as methylene chloride, is a colorless liquid. It is, or has been, used principally in paint strippers and removers, as a propellant in aerosols, in the manufacture of drugs, pharmaceuticals, film coatings, electronics, and polyurethane foam, as a metal cleaning solvent, and in the decaffeination process of coffee and tea.

History/Chronology

Date	Description
01- 1987	The oral RfD for dichloromethane was posted to the IRIS database.
02- 1990	The cancer assessment for dichloromethane was posted to the IRIS database.
03- Dec 2009	EPA initiated an interagency science consultation on the review of the draft Toxicological Review of Dichloromethane.
04- Mar 2010	EPA released an external review draft and the interagency review draft with comments.

Status

Following external peer review the assessment will be revised taking into consideration external peer review and public comments, will undergo a final EPA internal review and a review by a science discussion with other federal agencies and White House offices, then will be posted to the IRIS Web site.

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Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Toxicological Review of Dichloromethane (Interagency Science Consultation Draft) (PDF) (367 pp, 3.2 MB, about PDF)
Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF) (4 pp, 43.9 KB, about PDF)
OMB Comments of the Review of Dichloromethane (Dec 2009) (PDF) (10 pp, 63.5 KB, about PDF)
ATSDR/NCEH Comments of the Review of Dichloromethane (Jan 2010) (PDF) (1 pp, 31.2 KB, about PDF)
DOD Comments of the Review of Dichloromethane (Jan 2010) (PDF) (19 pp, 141.6 KB, about PDF)
DOD Comments on the External Peer Review Charge (Jan 2010) (PDF) (10 pp, 46.9 KB, about PDF)

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Document Related Link(s)

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US EPA

IRIS

Dichloromethane

CASRN 75-09-2 | DTXSID0020868