Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
CASRN 111-76-2 | DTXSID1024097
- Toxicological Review (PDF) (206 pp, 3.5 MB)
- IRIS Summary (PDF) (31 pp, 290.0 KB)
IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (External Review Draft)
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Overview
Citation
Background
The chemical is released to the environment primarily through the use of commercial and household cleaning products. EGBE is a high production volume chemical with an estimated 390 million pounds produced in the United States in 1992 (NTP, 2000). Human exposure to ethylene glycol monobutyl ether (EGBE) is predominantly occupational via inhalation and dermal contact. Individuals employed in the manufacture, processing, and handling of EGBE will have potentially higher exposures (ATSDR, 1998).
The primary routes of EGBE exposure to the general population are inhalation of contaminated indoor air and dermal contact with household products containing EGBE. The assessment will present reference values for the noncancer effects of EGBE (RfD and RfC), where supported by available data, and a cancer assessment.
History/Chronology
| Date | Description |
|---|---|
| Oct 1999 | EPA posted the first toxicological review for ethylene glycol mono-butyl ether (EGBE) in the IRIS database. |
| 2002 | EGBE is nominated for reassessment by EPA/OAQPS in response to a petition to delist this chemical filed by the ACC. |
| Apr 2008 | EPA released the external review draft (reassessment) of EGBE for public comment. |
| Sep 2008 | EPA announced the details for the external peer review meeting. [Federal Register Notice Sep 25, 2008] |
| Oct 2008 | EPA announced a public listening session. [Federal Register Notice Oct 1, 2008] |
| Oct 2009 | EPA released the comments from the first and second rounds of this review. |
| Nov 2009 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Ethylene Glycol Mono-Butyl Ether. |
| Mar 2010 | EPA released the final report and the interagency review draft with comments. |
Status
Additional Information
Download(s)
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of ETHYLENE GLYCOL MONOBUTYL ETHER (EGBE) (External Review Draft) (PDF) (166 pp, 2.7 MB, about PDF)
- Charge to External Peer Reviewers (PDF) (4 pp, 68.4 KB, about PDF)
- 1. Consolidated comments from the first round of external peer review (PDF) (213 pp, 926.8 KB, about PDF)
- 2. Consolidated comments from the second round of external peer review (PDF) (17 pp, 149.4 KB, about PDF)
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Document Related Link(s)
Federal Register Notices
Critical Effect Systems
Chemical Structure for
Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)
