trans-1,2-Dichloroethylene

Overview

EPA is releasing the draft report, Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Background

The draft Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

History/Chronology

Date	Description
Sep 1988	EPA posted the trans-1,2-dichloroethylene (RfD only).
Dec 1990	EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009	EPA hosted an interagency science consultation on the review of the draft IRIS Summary and Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene.
Sep 2009	EPA released an external review draft of the assessment for public review and comment.
Nov 2009	EPA announces the external peer review workshop to be held on December 17, 2009. [Federal Register Notice Nov 10, 2009]
Jan 2010	EPA releases the comments from the external review workshop and public comment period.
Jul 2010	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of cis- and trans-1,2-dichloroethylene.
Sep 2010	EPA releases the final report and IRIS Summary and the interagency review draft with comments.

Status

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• Toxicological Review of cis- and trans-1,2-dichloroethylene (Interagency Science Discussion Draft) (PDF)  (171  pp, 1.1 MB, about PDF)
• cis-1,2-DCE Summary (Interagency Science Discussion Draft) (PDF)  (12  pp, 78.1 KB, about PDF)
• trans-1,2-DCE Summary (Interagency Science Discussion Draft) (PDF)  (17  pp, 113.3 KB, about PDF)
• cis and trans dichloroethylene ATSDR Comments (PDF)  (2  pp, 42.0 KB, about PDF)
• cis and trans dichloroethylene CEQ comments (PDF)  (2  pp, 45.9 KB, about PDF)
• cis and trans dichloroethylene DoD comments (PDF)  (10  pp, 82.0 KB, about PDF)
• cis and trans dichloroethylene OMB comments (PDF)  (2  pp, 22.5 KB, about PDF)

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Document Related Link(s)

• IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Final Report)
• IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)
• IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)