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trans-1,2-Dichloroethylene

CASRN 156-60-5 | DTXSID7024031

  • Toxicological Review (PDF)  (174  pp, 1.1 MB, about PDF)
  • IRIS Summary (PDF)  (22  pp, 210.0 KB, about PDF)
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IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA is releasing the draft report, Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Background

The draft Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

History/Chronology
Date Description
Sep 1988 EPA posted the trans-1,2-dichloroethylene (RfD only).
Dec 1990 EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009 EPA hosted an interagency science consultation on the review of the draft IRIS Summary and Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene.
Sep 2009 EPA released an external review draft of the assessment for public review and comment.
Nov 2009 EPA announces the external peer review workshop to be held on December 17, 2009. [Federal Register Notice Nov 10, 2009]
Jan 2010 EPA releases the comments from the external review workshop and public comment period.
Jul 2010 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of cis- and trans-1,2-dichloroethylene.
Sep 2010 EPA releases the final report and IRIS Summary and the interagency review draft with comments.

Status

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • Toxicological Review of cis- and trans-1,2-dichloroethylene (Interagency Science Discussion Draft) (PDF)  (171  pp, 1.1 MB, about PDF)
  • cis-1,2-DCE Summary (Interagency Science Discussion Draft) (PDF)  (12  pp, 78.1 KB, about PDF)
  • trans-1,2-DCE Summary (Interagency Science Discussion Draft) (PDF)  (17  pp, 113.3 KB, about PDF)
  • cis and trans dichloroethylene ATSDR Comments (PDF)  (2  pp, 42.0 KB, about PDF)
  • cis and trans dichloroethylene CEQ comments (PDF)  (2  pp, 45.9 KB, about PDF)
  • cis and trans dichloroethylene DoD comments (PDF)  (10  pp, 82.0 KB, about PDF)
  • cis and trans dichloroethylene OMB comments (PDF)  (2  pp, 22.5 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Final Report)
  • IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)
  • IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)

Related Links

  • EPA Chemicals Dashboard - trans-1,2-Dichloroethylene
  • cis-1,2-Dichloroethylene
  • eChemPortal - Dichloroethylene

Critical Effect Systems

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Chemical Structure for
trans-1,2-Dichloroethylene

trans-1,2-Dichloroethylene

Synonyms

  • Acetylene dichloride, trans-
  • Dichloroethylene, trans-
  • Ethylene, 1,2-dichloro-, (E)-
  • RCRA Waste Number u079
  • trans-1,2-Dichloroethylene
  • trans-Acetylene dichloride
  • trans-Dichloroethylene
  • 1,2-Dichloroethylene, trans-
  • 156-60-5
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Last updated on February 02, 2017
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