IRIS

Urea

CASRN 57-13-6 | DTXSID4021426

IRIS Toxicological Review of Urea (Interagency Science Discussion Draft)

On this page:

Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the Risk Webmaster for assistance. Please use the contact us form if you need additional support.


Overview

EPA is releasing the draft report, Toxicological Review of Urea,, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Citation

U.S. EPA. IRIS Toxicological Review of Urea (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/005D, 2011.

Top of Page


Background

The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea. Urea, also known as carbamide, is an endogenous product of protein and amino acid catabolism. It can also be produced synthetically by combining ammonia, carbon monoxide, and sulfur in methanol. Urea is utilized in diesel selective catalyst reduction, in fertilizers and animal feed, plastics, flame-proofing agents, adhesives, flavoring agents and consumer goods such as liquid soaps, detergents and household cleaning products.

History/Chronology

Date Description
02- Jun 2010 EPA hosted the interagency science consultation on the draft Toxicological Review of Urea.
03- Sep 2010 EPA released the external review draft for public review and comment. EPA also announced a public listening session on Nov 16, 2010. [Federal Register September 28, 2010]
04- Nov 2010 EPA announced the external peer review meeting to be held on December 13, 2010. [Federal Register Nov 10, 2010]
05- Jan 2011 EPA released the comments from the external review workshop.
06- Jun 2011 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Urea.
07- Jul 2011 EPA released the final toxicological review and IRIS Summary for Urea and the interagency review draft with interagency review comments.

Status

This assessment has been loaded into the IRIS Web site and Database.

Top of Page

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.


Top of Page