Trichloroacetic acid

Overview

EPA has finalized the Toxicological Review of Trichloroacetic Acid: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.

Background

The Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

History/Chronology

Date	Description
Aug 2009	EPA hosted an interagency science consultation on the draft Toxicological Review of Trichloroacetic Acid.
Sep 2009	EPA released an External Reviewer Draft for public comment. EPA also announced a public listening session on Nov 4, 2009 [Federal Register Sep 24, 2009]
Nov 2009	EPA announced the external peer review meeting to be held on December 10, 2009. [Federal Register Nov 10, 2009]
Jan 2010	EPA released the comments from the external review workshop.
Jul 2011	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Trichloroacetic Acid.
Sep 2011	EPA releases the final toxicological review and IRIS Summary for Trichloroacetic Acid and the interagency science discussion draft with interagency comments.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

• IRIS Toxicological Review of Trichloroacetic Acid (PDF)  (270  pp, 1.8 MB, about PDF)
• IRIS Summary For Trichloroacetic Acid (PDF)  (26  pp, 237.3 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

• IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)
• IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Consultation Draft)
• IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Discussion Draft)