trans-1,2-Dichloroethylene

Overview

EPA has finalized the Toxicological Review of cis- & trans-1,2-Dichloroethylene: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.

Background

1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

History/Chronology

Date	Description
Sep 1988	EPA posted the trans-1,2-dichloroethylene (RfD only).
Dec 1990	EPA posted the cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009	EPA hosted an interagency science consultation on the review of the draft IRIS Summary and Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene.
Sep 2009	EPA released an external review draft of the assessment for public review and comment.
Nov 2009	EPA announces the external peer review workshop to be held on December 17, 2009. [Federal Register Notice Nov 10, 2009]
Jan 2010	EPA releases the comments from the external review workshop and public comment period.
Jul 2010	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of cis- and trans-1,2-dichloroethylene.
Sep 2010	EPA releases the final report and IRIS Summary and the interagency review draft with comments.

This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

• IRIS Toxicological Review of Cis- & Trans-1,2-Dichloroethylene (PDF)  (174  pp, 1.2 MB, about PDF)
• IRIS Summary for cis-1,2-Dichloroethylene (PDF)  (15  pp, 148.4 KB, about PDF)
• IRIS Summary for trans-1,2-Dichloroethylene (PDF)  (21  pp, 187.5 KB, about PDF)

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Document Related Link(s)

• IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)
• IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)
• IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)