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Carbon tetrachloride

CASRN 56-23-5 | DTXSID8020250

  • Toxicological Review (PDF)  (473  pp, 2.9 MB, about PDF)
  • IRIS Summary (PDF)  (20  pp, 354.5 KB, about PDF)
  • Key IRIS
    Values
  • Chemical
    Documents
  • Report
    Details
  • Other EPA
    Information

IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft)

On this page:

  • Overview
  • Background
  • Downloads

Alert
Alert Notice - This site contains archived material(s)

Archive disclaimer
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

EPA conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of carbon tetrachloride that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.

Background

Carbon tetrachloride has been used as a dry-cleaning agent, fabric-spotting fluid, solvent, reagent in chemical synthesis, fire extinguisher fluid, and grain fumigant, but its primary use was in chlorofluorocarbon (CFC) production. Production of this chemical peaked in the early 1970s; annual production has generally declined since the mid-1970s. The Consumer Product Safety Commission banned the use of carbon tetrachloride in consumer products in the 1970s. Decline in the use of carbon tetrachloride also accompanied EPA’s increased regulation of the use of CFCs in propellants, and the Montreal Protocol, which was implemented in the U.S. via Title VI of the Clean Air Act Amendments of 1990 and that called for a ban (with certain exemptions) on production and import of carbon tetrachloride.

History/Chronology
Date Description
1987 EPA posts the Carbon Tetrachloride IRIS assessment on the IRIS database (RfD and cancer assessment).
May 2008 EPA released the external review draft for public comment. [Federal Register Notice May 21, 2008]
Jun 2008 EPA announces the public listening session. [Federal Register Jun 24, 2008 ]
Sep 2008 EPA EPA announced the external peer review meeting to be held on October 14, 2008. [Federal Register Sep 9, 2008]
Nov 2008 EPA released the comments from the public comment period and external review meeting.
Nov 2009 EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Carbon Tetrachloride.
Mar 2010 EPA released the Toxicological Review and IRIS Summary for Carbon Tetrachloride and the interagency review draft with interagency review comments.

Status

Following the External Peer Review, the final assessment will be published on the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov website. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2008-0058 (for the docket ID) to comment on this report.

Download(s)

  • IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft) (PDF)  (404  pp, 5.4 MB, about PDF)
  • Charge to External Peer Reviewers (PDF)  (6  pp, 32.2 KB, about PDF)
  • Consolidated Comments from the External Peer Review (Final) (PDF)  (141  pp, 815.4 KB, about PDF)

If you have a disability and the format of any material on our web pages interferes with your ability to access the information, please reach out to us using the Contact Us about IRIS form for assistance. To enable us to respond in a manner most helpful to you, please indicate the nature of the accessibility problem, the web address of the requested material, your preferred format in which you want to receive the material (electronic format (ASCII, etc.), standard print, large print, etc.), and your contact information.

Document Related Link(s)

  • IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft)
  • IRIS Toxicological Review of Carbon Tetrachloride (Final Report)

Federal Register Notices

  • FR Notice: Sep 9, 2008
  • FR Notice: Jun 24, 2008
  • FR Notice: May 21, 2008

Related Links

  • EPA Chemicals Dashboard - Carbon tetrachloride
  • eChemPortal - Carbon tetrachloride

Critical Effect Systems

Hepatic
Hepatic

Tumor Sites

Endocrine
Endocrine

Hepatic
Hepatic

Chemical Structure for
Carbon tetrachloride

Carbon tetrachloride

Synonyms

  • Acritet
  • Benzinoform
  • Carbo tetrachloride
  • Carbon chloride
  • Carbon tet
  • Carbon tetrachloride
  • Carbona
  • Czterochlorek wegla
  • ENT 4,705
  • Fasciolin
  • Flukoids
  • Freon 10
  • Halon 104
  • Mecatorina
  • Methane tetrachloride
  • Methane, tetrachloro-
  • Necatorina
  • Necatorine
  • Perchloromethane
  • R 10
  • Tetrachloorkoolstof
  • Tetrachloormetaan
  • Tetrachlorkohlenstoff, tetra
  • Tetrachlormethan
  • Tetrachlorocarbon
  • Tetrachloromethane
  • Tetrachlorure de carbone
  • Tetrachorkohlenstoff Uvasol
  • Tetraclorometano
  • Tetracloruro di carbonio
  • Tetrafinol
  • Tetraform
  • Tetrasol
  • Univerm
  • Ventox
  • Vermoestricid
  • WLN: GXGGG
  • 56-23-5
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Last updated on February 02, 2017
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