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Cadmium

CASRN 7440-43-9 | DTXSID1023940

  • IRIS Summary (PDF)  (13  pp, 115.2 KB, about PDF)
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IRIS TOXICOLOGICAL REVIEW OF CADMIUM AND COMPOUNDS (EXTERNAL REVIEW DRAFT)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the IRIS Webmaster for assistance. Please use the contact us form if you need additional support.

Overview

The critical effect proposed for both the oral RfD and inhalation RfC is renal dysfunction as judged by minimal proteinuria/enzymuria. This critical effect is evidenced from several cross-sectional population studies and is best supported by the CadmiBel population study of Buchet et al. (Lancet 336, 1990, 699). A toxicokinetic model was used with the data in this study to calculate both a daily oral intake and a continuous air concentration of cadmium that would result in a 10% occurrence of minimal enzymuria (the critical effect) in the population at the age of 70. A representative level of dietary cadmium intake was integrated into the toxicokinetic model. The net oral intake (model - diet) at 0.7 ug/kg-day (7E-4 mg/kg-day) was designated the oral RfD. The modeled concentration of cadmium inhaled concomitant with this same representative dietary intake at 0. 65 ug/m3 (7E-4 mg/m3) was designated the inhalation RfC.
For both the RfD and the RfC, alternate backgrounds (and therefore different RfDs and RfCs ) are described in the Toxicological Review. Cadmium is classified as a probable human carcinogen by inhalation exposure based on limited evidence from human occupational studies and on animal inhalation studies in which lung cancer was observed. Evidence for cadmium carcinogenicity via the oral route is judged inadequate.

(CAS No. 7440-43-9)

Download(s)

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

  • Zip file of entire cadmium document. (ZIP)  (508.8 KB, about ZIP)
  • Reference Concentration for Chronic Inhalation (RfC) (PDF)  (13  pp, 59.6 KB, about PDF)
  • Carcinogenicity Assessment for Lifetime Exposure (PDF)  (12  pp, 48.8 KB, about PDF)
  • Appendix C, Benchmark Dose Calculations (PDF)  (19  pp, 105.5 KB, about PDF)
  • Reference Dose for Chronic Oral Exposure (RfD) (PDF)  (11  pp, 33.2 KB, about PDF)
  • Toxicological Review of Cadmium and Compounds (External Review Draft) (PDF)  (108  pp, 399.4 KB, about PDF)

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Related Links

  • EPA Chemicals Dashboard - Cadmium
  • eChemPortal - Cadmium

Critical Effect Systems

Urinary
Urinary

Tumor Sites

Respiratory
Respiratory

Chemical Structure for
Cadmium

Cadmium

Synonyms

  • C.I. 77180
  • Cadmium
  • Kadmium
  • 7440-43-9
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Last updated on August 16, 2010
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