Trichloroacetic acid

Overview

EPA is releasing the draft report, Toxicological Review of Trichloroacetic Acid (TCA), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Background

The draft Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

History/Chronology

Date	Description
Aug 2009	EPA hosted an interagency science consultation on the draft Toxicological Review of Trichloroacetic Acid.
Sep 2009	EPA released an External Reviewer Draft for public comment. EPA also announced a public listening session on Nov 4, 2009 [Federal Register Sep 24, 2009]
Nov 2009	EPA announced the external peer review meeting to be held on December 10, 2009. [Federal Register Nov 10, 2009]
Jan 2010	EPA released the comments from the external review workshop.
Jul 2011	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Trichloroacetic Acid.
Sep 2011	EPA releases the final toxicological review and IRIS Summary for Trichloroacetic Acid and the interagency science discussion draft with interagency comments.

Status

This assessment has been loaded into the IRIS Web site and Database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of Trichloroacetic Acid (Interagency Science Discussion Draft) (PDF)  (275  pp, 1.6 MB, about PDF)
• Trichloroacetic Acid Summary (Interagency Science Discussion Draft) (PDF)  (20  pp, 139.6 KB, about PDF)
• EPA's Response & Interagency Science Discussion Comments (PDF)  (11  pp, 117.2 KB, about PDF)
• 1. NIEHS NTP TCA IASD Comments (PDF)  (1  pp, 53.7 KB, about PDF)
• 2. OMB TCA IASD comments (PDF)  (4  pp, 43.9 KB, about PDF)

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Document Related Link(s)

• IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)
• IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Interagency Science Consultation Draft)
• IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Final Report)