Biphenyl
CASRN 92-52-4 | DTXSID4020161
- Toxicological Review (PDF) (225 pp, 4.82 M)
- IRIS Summary (PDF) (12 pp, 111 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(12 pp, 111 K)
Last Updated: 08/27/2013
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Urinary | 5 x 10 -1 | Renal papillary mineralization in male F344 rats |
BMDL
10
(HED<sub>99</sub>):
13.9
mg/kg-day |
30
MF: 10 |
Medium/High |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(12 pp, 111 K)
Last Updated: 08/27/2013
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(12 pp, 111 K)
Last Updated: 08/27/2013
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Suggestive evidence of carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for biphenyl provides “suggestive evidence of carcinogenic potential” based on increased incidence of urinary bladder tumors (transitional cell papillomas and carcinomas) in male F344 rats (Umeda et al., 2002) and liver tumors (hepatocellular adenomas and carcinomas) in female BDF1 mice (Umeda et al., 2005) exposed to biphenyl in the diet for 104 weeks, as well as information on mode of carcinogenic action. The carcinogenic potential of biphenyl in humans has not been investigated.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 111 K)
Oral Slope Factor:
8
x 10-3
per mg/kg-day
Drinking Water Unit Risk:
2.3
x 10-7
per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic
Tumor type(s): Liver adenomas or carcinomas (Umeda et al., 2005)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 111 K)
Information reviewed but value not estimated.
Aug 2013: IRIS Toxicological Review of Biphenyl (Final Report) (Report)
Apr 2013: IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft) (Report)
Sep 2011: IRIS Toxicological Review of Biphenyl (External Review Draft) (September 2011) (Report)
Jul 2011: IRIS Toxicological Review of Biphenyl (Interagency Science Consultation Draft) (Report)
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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